Effect of tandem lesions on haemodynamic parameters: an experimental study

Diken, Adem İlkay; Yalçınkaya, Adnan; Hanedan, Onur; Günertem, Eren; Demir, Emre; Erol, Emir

doi:10.5603/kp.a2017.0163

Cited by 5 publications

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“…For more than two decades, one of the major courses of activity in cardiology has been the study of hemodynamic effects in human coronary arteries by simulation methods prior to progressing to the clinical level. The effect of stenosis in coronary arteries has been studied particularly by mechanical simulation in vitro methods [19] as well as by porcine model in vivo simulation methods [20].…”

Section: Uniqueness Of the Combined Numerical Simulation And Multi-artery Ffr Methodsmentioning

confidence: 99%

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2019

OJCR

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The LMCA is the most important coronary artery since it provides the blood supply to almost the entire left ventricle [1]. The LMCA was first assessed by an angiographic method which was problematic because of inherent difficulties associated with LMCA like short vessel segment, lack of a reference vessel, eccentricity and other unfavourable phenomena [2]. Assessment of LMCA was also made extensively by IntraVascular UltraSound (IVUS) for considerable period of time [3]. In many cases the LMCA has a particular distribution and nature of plaque. LMCA plaque was found to be diffuse and to extend into the proximal LAD, LCx arteries in most cases [4]. This undoubtedly complicates the treatment of stenotic LMCA. The results and consequences of the first percutaneous interventions in LMCA showed that at that time percutaneous transluminal coronary angioplasty (PTCA) could not be acceptable as a standard treatment [5]. This led to the consensus that PTCA is contraindicated for treating a stenotic unprotected LMCA (namely without even one bypass graft to LAD and/or LCx arteries) [6]. In view of the progress in the percutaneous coronary

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Section: Uniqueness Of the Combined Numerical Simulation And Multi-artery Ffr Methodsmentioning

confidence: 99%

Untitled

2019

OJCR

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Section: Uniqueness Of the Combined Numerical Simulation And Multi-artery Ffr Methodsmentioning

confidence: 99%

Untitled

2019

OJCRR

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“…However, the location, morphology, and extent of the stenotic lesion(s) are equally important in determining the severity of the disease, in addition to the rate of occlusion. In fact, the cumulative stenotic effect of multiple lesions may result in greater hemodynamic impairment than that of a single lesion with the same degree of stenosis 4,5 . Furthermore, multiple stenoses are more likely to contribute to the further deterioration of carotid plaque 6 .…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the cumulative stenotic effect of multiple lesions may result in greater hemodynamic impairment than that of a single lesion with the same degree of stenosis. 4 , 5 Furthermore, multiple stenoses are more likely to contribute to the further deterioration of carotid plaque. 6 Therefore, identifying the vessels and mechanisms responsible for ischemic stroke in patients with multiple craniocervical stenoses is imperative.…”

Section: Introductionmentioning

confidence: 99%

Effect of collateral circulation in patients with multiple craniocervical artery stenoses

Gao,

Liu,

et al. 2023

Clinical Translational Sci

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Based on previous findings, collateral circulation in the brain is vital in mitigating cerebral ischemia's effects and influencing stroke risk. This retrospective study examined collateral circulation, admission ischemic stroke status, and long‐term recurrence in patients with multiple craniocervical artery stenoses. Consecutive symptomatic internal carotid artery (ICA) stenosis patients from the First Affiliated Hospital of Soochow University were recruited. Baseline data including medical histories and neurological function at admission were collected. Imaging techniques assessed collateral compensative capacity. Multivariate logistic regression analysis was used to investigate the association between collateral circulation and case status. A total of 559 patients with symptomatic ICA stenosis were included, among whom 153 (27.4%) had concurrent moderate to severe vertebro‐basilar artery (VBA) stenosis. Dizziness, weakness/numbness, and slurring of speech were the primary symptoms in all patients. Over 36 months, 71 (12.7%) patients experienced a recurrence of acute ischemic stroke (AIS). In multivariate analysis, collateral circulation was found to be negatively associated with AIS (regional leptomeningeal collateral [rLMC] scores: OR: 0.798, 95% CI: 0.743–0.857, p < 0.001; Tan scores: OR: 0.478, 95% CI: 0.336–0.679, p < 0.001). Meanwhile, the collateral circulation scores were significantly associated with the recurrence of AIS within 3 years (rLMC scores: OR: 0.926, 95% CI: 0.860–0.997, p = 0.042; Tan scores: OR: 0.467, 95% CI: 0.306–0.712, p < 0.001). Most associations remained significant in the subgroup of patients with VBA stenosis. Favorable collateral circulation in multiple craniocervical artery stenosis patients reduced long‐term ischemic event recurrence. Stratifying treatment risks is essential for optimizing outcomes.

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Effect of tandem lesions on haemodynamic parameters: an experimental study

Cited by 5 publications

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Effect of collateral circulation in patients with multiple craniocervical artery stenoses

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