2012
DOI: 10.3748/wjg.v18.i35.4875
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Effect of Tangweian Jianji on upper gastrointestinal remodeling in streptozotocin-induced diabetic rats

Abstract: TWAJJ (high dose) treatment partly restored the morphometric and biomechanical remodeling of the upper gastrointestinal tract in diabetic rats.

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Cited by 11 publications
(23 citation statements)
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“…The small intestine is the major site of gastrointestinal digestion and absorption with intestinal villi offering a large area for secretion and absorption of many nutrients (Betton, ). In previous experimental DGID studies, the following was observed, especially in the small intestine: a prominent proliferation of intestinal wall (Liu et al ., ); motility disorders; and increase in wet weight (Zhao et al ., ,b) and in length (Durmus‐Altun et al ., ). Furthermore, diabetic rats showed hypoinsulinemia therefore developed hyperglycaemia, high food intake and low body mass.…”
Section: Discussionmentioning
confidence: 99%
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“…The small intestine is the major site of gastrointestinal digestion and absorption with intestinal villi offering a large area for secretion and absorption of many nutrients (Betton, ). In previous experimental DGID studies, the following was observed, especially in the small intestine: a prominent proliferation of intestinal wall (Liu et al ., ); motility disorders; and increase in wet weight (Zhao et al ., ,b) and in length (Durmus‐Altun et al ., ). Furthermore, diabetic rats showed hypoinsulinemia therefore developed hyperglycaemia, high food intake and low body mass.…”
Section: Discussionmentioning
confidence: 99%
“…Morphological changes in the small intestine, such as increase of the length and prolonged transit time were observed in diabetic animals (Durmus‐Altun et al ., ). Western medical treatment of DGID is mainly focused on symptomatic control with improvement of gastric motility, using promoting agents, for example, oral antidiabetic drugs, and supportive measures based on blood glucose control (Liu et al ., ). Moreover, the use of plant foods to oppose hyperglycaemia has been practiced by herbal medicine (Büyükbalci & El, ; Omoruyi, ; Dixit & Kar, ; Kumar & Reddy, ).…”
Section: Introductionmentioning
confidence: 99%
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“…). The esophagus became stiffer in the circumferential and longitudinal directions, as well as in the shear direction, in STZ‐induced type 1 diabetic rats during the development of DM . Detailed layered wall biomechanical analysis showed that the biomechanical remodeling in the esophageal mucosa–submucosa layer 28 days after induction of diabetes was characterized by increased circumferential stiffness .…”
Section: Diabetes‐induced Remodeling In the Esophagusmentioning
confidence: 99%
“…Animal studies have clearly demonstrated that esophageal morphodynamic remodeling occurs in both type 1 and type 2 diabetic rats . The total wall thickness and wall cross‐sectional area increased in streptozotocin (STZ)‐induced type 1 diabetic rats .…”
Section: Diabetes‐induced Remodeling In the Esophagusmentioning
confidence: 99%