Effect of tannic acid-templated mesoporous silica nanoparticles on iron-induced oxidative stress and liver toxicity in rats

Javdani, Hossein; Etemad, Leila; Moshiri, Mohammad; Zarban, Asghar; Hanafi‐Bojd, Mohammad Yahya

doi:10.1016/j.toxrep.2021.09.005

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…Tannic acid has the ability to form a complex with polyvalent cations like Cd 2+ , Co 2+ , Cr 3+ , Zn 2+ and Fe 2+ . [118][119][120][121] Kim et al developed tannic acid-Fe(III) complex deposition on the surface of MSNs to provide the pH-and glutathione-responsive nanocarrier. The results of in vitro release study revealed sustainable Cur release at pH 7.4, while a rapid Cur release was observed by lowering the pH to 6.0 or 4.5.…”

Section: Glutathione (Gsh)-responsive Cur-loaded Msnsmentioning

confidence: 99%

Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Iranshahy,

Hanafi-Bojd,

Aghili

et al. 2023

RSC Adv.

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Section: Glutathione (Gsh)-responsive Cur-loaded Msnsmentioning

confidence: 99%

Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Iranshahy,

Hanafi-Bojd,

Aghili

et al. 2023

RSC Adv.

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Oral administration of tannic acid attenuates dyslipidemia, hyperglycemia, and oxidative stress in high‐fat and fructose diet‐induced obesity in rats

Ejiofor,

Agwamba,

Egedigwe‐Ekeleme

et al. 2024

Food Safety and Health

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Obesity and diabetes are considered life‐threatening conditions, characterized by increased oxidative stress, insulin resistance, hepatotoxicity, hyperglycemia, and hypercholesterolemia. Therefore, we studied the effects of tannic acid in a high‐fat and fructose‐diet‐induced rat model of obesity. Administration of tannic acid at doses of 200 and 400 mg/kg significantly reduced fasting blood glucose concentration, reversed disoriented lipid profile, decreased liver enzyme activities, and inhibited oxidative stress compared to the high‐fat, high‐sugar group. Histopathological examination showed preserved pancreas and liver architecture in the tannic acid‐administered groups. The in vitro inhibitory activity of tannic acid against alpha‐amylase, alpha‐glucosidase, and pancreatic lipase showed good inhibitory potential. Molecular docking studies showed high binding affinity and more hydrogen bond interactions between tannic acid and receptor proteins (alpha‐amylase, alpha‐glucosidase, and pancreatic lipase) implicated in obesity and diabetes. In conclusion, tannic acid prevented the onset of oxidative stress, preserved the liver, and restored the disoriented lipid profile in high‐fat and fructose diet‐induced obesity in rats.

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Drug delivery systems based on mesoporous silica nanoparticles for the management of hepatic diseases

Liu,

et al. 2024

Acta Pharmaceutica Sinica B

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Effect of tannic acid-templated mesoporous silica nanoparticles on iron-induced oxidative stress and liver toxicity in rats

Abstract: Graphical abstract

Cited by 4 publications

References 54 publications

Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Oral administration of tannic acid attenuates dyslipidemia, hyperglycemia, and oxidative stress in high‐fat and fructose diet‐induced obesity in rats

Drug delivery systems based on mesoporous silica nanoparticles for the management of hepatic diseases

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