Effect of tantalum interlayer on hydroxyapatite biointerface for orthopedic applications

Bartkowiak, Amanda; Zabila, Y.; Menaszek, E.; Zarzycki, A.; Perzanowski, Marcin; Marszałek, M.

doi:10.1016/j.surfcoat.2022.128882

Cited by 7 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Miyazaki et al 22 reported HA nucleation in Ta metallic surface when submitted to a thermochemical treatment. Bartkowiak et al 23 observed the bioactivation of Ti substrate coated with Ta oxide.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Physical, morphological and bioactive properties of Co–Cr–W–Ta alloys: Influence of insertion of tantalum and surface thermochemical treatment on bioactivity

et al. 2023

View full text Add to dashboard Cite

The development of bioactivity in bioinert metallic alloys is a field of interest aiming to improve some aspects of these materials for implant applications. New Co 63 Cr 28 W 9-x Ta x alloys with different Ta concentrations (x = 0, 2, 4, 6, and 9% w/w) were synthesized in the work reported here. The alloys were characterized by x-ray diffraction, volumetric density, Vickers microhardness, atomic force microscopy, scanning electron microscopy (SEM), and energy-dispersion x-ray spectroscopy (EDS). Bioactivity properties were evaluated by in vitro tests with simulated body fluid (SBF). In vivo assays were performed to assess biocompatibility. The influence of surface thermochemical treatment and Ta insertion on the bioactive properties of the alloys was investigated. The results showed that the alloy structure comprises εCo and αCo phases, with cobalt as a matrix with Cr, W, and Ta as a solid solution. TaCo 2 phase is observed in the alloys with 4, 6, and 9% w/w of Ta, and its amount increase as Ta concentration increases. Volumetric density is reduced (from 8.78 ± 0.06 to 8.56 ± 0.09 g/cm 3 ) as Ta concentration increases (from 0% to 9% w/w) mainly due to the lower density of the tantalum compared to the tungsten metal. On the other hand, the TaCo 2 phase contributes to the increase of Vickers's hardness by $17.6% for the alloy with 9% Ta (394.7 ± 8.1 HV) compared with Co 63 Cr 28 W 9 (336 ± 5 HV). The topographic analysis showed increased roughness and adhesion due to the nucleation of Ta 1.1 O 1.05 and Ca 2 Ta 2 O 7 crystals after surface thermochemical treatment. The roughness and adhesion increase from 16.9 ± 0.6 nm and 8.3 ± 1.8 nN (untreated surface) to 255.7 ± 17.7 nm and 24.1 ± 12.6 nN (treated surface), respectively, for the Co 63 Cr 28 Ta 9 alloy. These results suggest that thermochemical treatment provides surface conditions favorable to hydroxyapatite (HA) nucleation. The SEM and EDS data showed the nucleation of spongy structures, consistent with HA, composed mainly of Ca and P, indicating that oxides tantalum promoted a bioactive response on the sample's surface. The biological assay corroborated the alloy's safety and applicability, highlighting its potential in biomedical application since no harmful effects were observed.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Moreover, the literature reports apatite gown on Ta metal surface after immersion in simulated body fluid (SBF) 14,22 . Bartkowiak and co‐authors 23 observed in vitro bioactivity on Ti substrates covered with Ta layer. Thus, adding Ta metal to Co–Cr alloys can be an interesting approach to induce bioactivity in these alloys.…”

Section: Introductionmentioning

confidence: 99%

Physical, morphological and bioactive properties of Co–Cr–W–Ta alloys: Influence of insertion of tantalum and surface thermochemical treatment on bioactivity

et al. 2023

View full text Add to dashboard Cite

show abstract

“…CaP-based materials are a class of substances with physical and chemical properties that are similar to those of natural human bones. Typical CaP-based materials are CaP and HA, which have superior bone conductivity and can promote bone formation [147]. By loading HA coating on the surface of tantalum, Antonio et al, confirmed that it can improve the biocompatibility of tantalum and stimulate new bone formation [119].…”

Section: Cap-based Materialsmentioning

confidence: 99%

Progress of research on the surface functionalization of tantalum and porous tantalum in bone tissue engineering

Li,

Zhu,

Che

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

Tantalum and porous tantalum are ideal materials for making orthopedic implants due to their stable chemical properties and excellent biocompatibility. However, their utilization is still affected by loosening, infection, and peripheral inflammatory reactions, which sometimes ultimately lead to implant removal. An ideal bone implant should have exceptional biological activity, which can improve the surrounding biological microenvironment to enhance bone repair. Recent advances in surface functionalization have produced various strategies for developing compatibility between either of the two materials and their respective microenvironments. This review provides a systematic overview of state-of-the-art strategies for conferring biological functions to tantalum and porous tantalum implants. Furthermore, the review describes methods for preparing active surfaces and different bioactive substances that are used, summarizing their functions. Finally, this review discusses current challenges in the development of optimal bone implant materials.

show abstract

“…Synthetic HA has been successfully used to fabricate biomaterials, osteogenic coatings, and other materials of biomedical interest [1][2][3][4][5]. There are different methodologies for fabrication of calcium phosphates, such as solid-state syntheses [6][7][8][9], hydrothermal syntheses [10][11][12][13][14][15], biomimetic systems [16][17][18], electrochemical process [19][20][21], and sol-gel methods [5,[22][23][24]. However, it should be mentioned that synthetic methods involving high-temperature treatment, such as solid-state reaction or sol-gel, usually form large, agglomerated particles and do not lead to the anisotropic growth of the crystals.…”

Section: Introductionmentioning

confidence: 99%

Photodeposition of Hydroxyapatite into a Titanium Dioxide Nanotubular Layer Using Ca(EDTA) Complex Decomposition

et al. 2023

View full text Add to dashboard Cite

A new photocatalytic hydroxyapatite (HA) synthesis method has been developed. This method is based on the unique ability of the TiO2 photocatalyst to decompose the Ca(EDTA) complex under UV illumination. As a result, released Ca2+ ions react with PO43− ions forming the HA particles. The photocatalytic formation of hydroxyapatite is found to have a fractional order, which may indicate the complex reaction mechanism and the presence of several limiting stages. The TNT-HA samples were studied by XRD, FTIR, SEM, GDOES, and biocompatibility study. High biocompatibility of the surfaces is proven by pre-osteoblast cell growth.

show abstract

Effect of tantalum interlayer on hydroxyapatite biointerface for orthopedic applications

Cited by 7 publications

References 49 publications

Physical, morphological and bioactive properties of Co–Cr–W–Ta alloys: Influence of insertion of tantalum and surface thermochemical treatment on bioactivity

Physical, morphological and bioactive properties of Co–Cr–W–Ta alloys: Influence of insertion of tantalum and surface thermochemical treatment on bioactivity

Progress of research on the surface functionalization of tantalum and porous tantalum in bone tissue engineering

Photodeposition of Hydroxyapatite into a Titanium Dioxide Nanotubular Layer Using Ca(EDTA) Complex Decomposition

Contact Info

Product

Resources

About