Effect of Taraxacum officinale L. ethanol extract against kidney injuries induced by paracetamol in rats

Abstract

Background/Aim: The biochemical effects of dandelion (D) ethanol extract on blood and renal tissue in rats induced by paracetamol (PRC) were examined in this study. Methods: In this study was utilized 36 Sprague Dawley male rats, aged 5 months. Rats were divided 6 groups of 6 rats each, randomly. Control group (C), D200 group, D250 group, PRC group, PRC+D200 group, PRC+D250 group, was given orally per os (p.o) in a single dosage (2 g/kg/b.w.) and dandelion extract (200-250 mg/kg) was given intraperitoneally (i.p) for 8 days. Results PRC raised plasma levels of urea, uric acid, and creatinine, as well as malondialdehyde, nitrate, and nitrite in kidney tissue. Furthermore, antioxidant levels/activities in renal tissue were reduced. Dandelion reduced plasma levels of urea, uric acid, and creatinine, as well as lipid peroxidation, nitrat, and nitrit in kidney tissue, while simultaneously increasing antioxidant activities. Conclusion: In this study was investigated that dandelion ethanol extract can be used excellent protection against PRC damage.

Beyond Conventional Treatment: Exploring Natural Therapies for Paracetamol Overdose

“…Dandelion contains many antioxidants, and antiinflammatory and antimicrobial agents including terpenes, phenolic acids, flavonoids, alkaloids, peptides, oligosaccharides, polysaccharides, calcium, potassium, vitamins A, C, and nicotinic acid, with therapeutic effects on obesity, cancer, heart disease, diabetes, and gastrointestinal disorders (8,10,49) .…”

“…Studies have shown that dandelion extract can reduce the severity of paracetamol-induced liver damage by boosting antioxidant activity, inhibiting lipid peroxidation, activating the Nrf-2/HO-1 pathway, and inhibiting the apoptosis pathway (8,10,49,50) . The animal dosage used in these studies ranges from 100-400 mg/kg/day.…”