Effect of Tea-leaf Saponin on Blood Pressure of Spontaneously Hypertensive Rats

Sagesaka-Mitane, Yuko; Sugiura, Tomomi; Miwa, Yosuke; Yamaguchi, Kazumasa; Kyuki, Kohei

doi:10.1248/yakushi1947.116.5_388

Cited by 48 publications

(28 citation statements)

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“…In recent years, some studies have reported the anti-allergic, 6 antihypertensive, 7 antimicrobial and anti-inflammatory 8 effects of teasaponin, but yet the inhibitory effects of teasaponin on pancreatic lipase activity have been not reported. Pancreatic lipase is the most important enzyme for the digestion of dietary triacylglycerols.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor

et al. 2001

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OBJECTIVE: Based on the inhibitory effects of teasaponin on pancreatic lipase activity in vitro, this study was performed to clarify whether teasaponin prevented obesity induced in mice by a high-fat diet for 11 weeks. DESIGN: For in vitro experiments, assay for the inhibitory effects of teasaponin on pancreatic lipase activity was performed by measuring the rate of release of oleic acid from triolein in an assay system using triolein emulsified with lecithin, gum arabic, Triton X-100 or 4-methylumbelliferyloleate. For in vivo experiments, female ICR mice were fed a high-fat diet with or without 0.5% teasaponin for 11 weeks. RESULTS: Teasaponin competitively inhibited the hydrolysis of triolein emulsified with lecithin, gum arabic, Triton X-100 or 4-methylumbelliferyloleate. Teasaponin inhibited the elevations of plasma triacylglycerol levels 3, 4 and 5 h after oral administration of lipid emulsion containing corn oil. Teasaponin suppressed the increases in body, parametrial adipose tissue weights and diameter in adipose cell size induced by a high-fat diet. Furthermore, feeding a high-fat diet plus teasaponin had no effect on stool frequency and content, but significantly increased triacylglycerol contents in feces as compared to feeding a high-fat diet. CONCLUSIONS: The anti-obesity effects of teasaponin in high-fat diet-treated mice may be partly mediated through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.

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Section: Discussionmentioning

confidence: 99%

Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor

et al. 2001

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“…Tea polyphenols contained in green tea leaves ( Camellia sinensis L. ) are known to have antiviral [1], antioxidative [2, 3], antimutagenic [4], anticarcinogenic [5], antiobesity [6], and antihypertensive activities [7–9]. Tea leaves contain tea polyphenols such as catechins, so regular consumption of green tea is thought to be beneficial to one's health.…”

Section: Introductionmentioning

confidence: 99%

“…Long-term consumption of tea has been reported to result in antihypertensive activity in spontaneously hypertensive rats (SHRs) [7, 8] while another study reported antihypertensive activity with a single administration of tea [9]. The antihypertensive activity of tea polyphenols is thought to occur via the inhibition of angiotensin-converting enzyme (ACE) activity [11].…”

Section: Introductionmentioning

confidence: 99%

Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as “Support for Normal Blood Pressure”

et al. 2011

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The ACE inhibitory activities of mixtures of FOSHUs (Healthya, Goma-Mugicha, Lapis Support and Ameal) were examined in order to identify any antihypertensive interactions. Among combinations of Healthya with other samples that contain active peptides, only that with Ameal was found to have no inhibitory activity. Enhanced activity was observed in 2 other mixtures. The activity of a mixture of tea polyphenols and the whey component extracted from an Ameal solution was significantly decreased, thus demonstrating that whey protein lowered the ACE inhibitory activity of Healthya. Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with Ameal failed to decrease SBP at the same time points. In conclusion, the simultaneous intake of tea and FOSHUs that contain active peptides might affect daily self-antihypertensive management via enhancement or suppression of ACE inhibitory activity.

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“…in spontaneously hypertensive rats was as potent as that of enalapril at a dose of 3 mg/kg p.o., but it was not correlated with an inhibitory activity against angiotensin I converting enzyme (ACE I ) (IC50 > 10 mg/mL ) [57]. A new furostanol-saponin of Allium macrostemon was shown to significantly inhibit the platelet aggregation induced by aggregating agents (IC50 = 0.8 mM) [58].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Biologically and Pharmacologically Active Saponins from Plants: Recent Advances

Lacaille-Dubois

2000

Saponins in Food, Feedstuffs and Medicinal Plants

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Effect of Tea-leaf Saponin on Blood Pressure of Spontaneously Hypertensive Rats

Cited by 48 publications

References 0 publications

Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor

Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor

Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as “Support for Normal Blood Pressure”

Biologically and Pharmacologically Active Saponins from Plants: Recent Advances

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