Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota

Lee, Hui Cheng; Jenner, Andrew; Low, Chin Seng; Lee, Yuan Kun

doi:10.1016/j.resmic.2006.07.004

Cited by 615 publications

(471 citation statements)

References 45 publications

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“…In recent years there has been a renewal of interest in the impact of polyphenolic components of common foods on gut microbial ecology, in accordance with the emerging consensus that the gut microbiota may play a crucial role in the potential health benefits of dietary polyphenols. To date, some in vitro studies examining the effect of tea catechins on intestinal microbiota have been reported (16,17). The present study aimed to evaluate the in vivo effect of EGCG, the most abundant polyphenol in green tea, on the gut microbial composition of rats.…”

Section: Discussionmentioning

confidence: 99%

“…The small-intestinal absorption of tea catechins is extremely poor (15), suggesting that catechins could reach the large intestine, and be incorporated into the gut microbiota complex. The literature has demonstrated that the growth in vitro of certain pathogenic bacteria was significantly repressed by polyphenols in green tea (16,17). However, there are remarkably few studies investigating the in vivo influence of tea catechins on the composition and activity of the gut microbial community.…”

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confidence: 99%

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Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Unno

Sakuma

Mitsuhashi

2014

J Nutr Sci Vitaminol

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Summary Alterations in gut microbiota composition offer insights that may be relevant for several chronic conditions, including obesity. This study aimed to evaluate the effect of (2)-epigallocatechin gallate (EGCG) on the modulation of gut microbiota and biomarkers of colonic fermentation end-products in rats. Rats were fed an assigned diet of either a control diet, a 0.3% (w/w) EGCG diet, or a 0.6% (w/w) EGCG diet for 4 wk. Compared to the control group, the addition of 0.6% EGCG to the diet brought about a significant increase in the starch and protein contents in the feces collected in the fourth week of feeding, but the relative weights of abdominal adipose tissues of rats were inversely suppressed. Hostspecific bacterial community composition, as determined by terminal restriction fragment length polymorphism (T-RFLP) patterns for fecal 16S ribosomal RNA, showed a significant response in the reduced occupation of Clostridium spp. and an increased trend of Bacteroides by dietary supplementation with EGCG. The 0.6% EGCG diet also influenced the status of Bifidobacterium and Prevotella to a lesser extent. Interestingly, the cecum of rats fed the 0.6% EGCG diet contained lower levels of acetic and butyric acids, whereas EGCG had little influence on the cecal level of propionic acid. EGCG also reduced the cecal p-cresol concentration in a dose-dependent fashion. In conclusion, dietary EGCG affects the growth of certain species of gut microbiota in rats and is associated with the cecal pattern of short chain fatty acids which could be responsible for regulating energy metabolism in the body.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Unno

Sakuma

Mitsuhashi

2014

J Nutr Sci Vitaminol

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“…Some of these act through the amelioration of insulin resistance, whereas some act through the modulation of the gut microbiome (146,147). These compounds can reduce pathogen bacteria and increase lactic acid bacteria, such as some strains of Bifidobacteria (148). The manipulation of the gut microbiota may be 1 of the mechanisms of action involved in the beneficial effects of polyphenols on NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

Mokhtari

Gibson

Hekmatdoost

2017

Advances in Nutrition

138

100

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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can modulate the gut microbiome and several metabolic pathways involved in NAFLD development, shows a potential tripartite relation between the gut, diet, and the liver. In this review, we summarize the current evidence that supports the association between NAFLD, the gut microbiome, and the role of diet. Adv Nutr 2017;8:240-52.

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“…lee et al [22] reported that intestinal bacteria metabolize phenolics and produce different aromatic metabolites which can be retained by the bacterial cell and this bacterial activity can explain the effects on the growth. also, metabolites released into the media may influence the growth of bacteria that produce these metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…helveticus T159 cultivated both for 2 h and 6 h. Moreover, the MBC of this ester was 2 μg/ml, whereas in the case of free 4-hydroxybenzoic acid MBC was not detected. In the case of two benzoic acid derivatives, 4-OH-phenylacetic acid (7) and methyl syringate (22), no inhibitory effect was observed towards both strains.…”

Section: The Antibacterial Activity Of Phenolic Acids and Their Non-ementioning

confidence: 99%

The role of ferulic acid esterase in the growth of Lactobacillus helveticus in the presence of phenolic acids and their derivatives

Waśko

Szwajgier

Polak-Berecka

2013

Eur Food Res Technol

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Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota

Cited by 615 publications

References 45 publications

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

The role of ferulic acid esterase in the growth of Lactobacillus helveticus in the presence of phenolic acids and their derivatives

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