Introduction Preliminary occupational therapy intervention studies are much needed. Although the importance of Obsessive Compulsive Disorder (OCD) recognized as highly restrictive for individuals, there are only e few studies addressing occupational therapy interventions for them. Objectives This study aimed to examine the effectiveness of a person-centered, holistic occupational therapy assessment and interventions using the conceptual model of practice, the Model of Human Occupation (MOHO), for persons diagnosed with OCD. Method A demographic information form, Occupational Self-Assessment (OSA), Model of Human Occupation Screening Tool (MOHOST), and a semi-structured interview form were employed pre and post-intervention. The Pittsburgh Sleep Quality Index was also used for Case 2. Results After 16 sessions, the findings showed positive results of the person-centered occupational therapy intervention on occupational participation and performance in both cases. Conclusion This study highlights the effectiveness of occupational therapy intervention on occupational participation and performance, based on the MOHO approach for two cases of individuals with OCD.