Effect of temazepam on ventilatory response at moderate altitude

Röggla, Georg; Moser, Berthold; Röggla, M

doi:10.1136/bmj.320.7226.56

Cited by 21 publications

(14 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We would like to draw attention to the fact that other sedating substances have a similar effect. Long-acting and shortacting benzodiazepines impair respiration at high altitude at doses which have no effect on respiration at low altitude [2,3]. Similar results were found after 50 g alcohol at moderate altitude [4].…”

Section: Emergency Anaesthesia At High Altitudesupporting

confidence: 76%

“…We would point out that it was Professor Reynolds' case series that recently highlighted the risks of causing severe neurological damage with a spinal needle and so we do have evidence that damage is caused using current techniques of spinal needle insertion [1]. Both cadaveric and radiological studies have found that Tuffier's line crosses the body of L4 or the L4 ⁄ 5 disc space in 78.6% of people [2,3]. One space above Tuffier's line should be L3 ⁄ 4, one below L4 ⁄ 5 and two above, L2 ⁄ 3.…”

Section: A Replymentioning

confidence: 99%

“…We note, however, that using the incremental advancement technique, spinal anaesthesia failed in six of the 100 patients even though women likely to be at greater risk of spinal failure (BMI > 40 kg.m )2 and 'abnormal body habitus') were excluded from study. We wonder if the authors consider this an acceptable failure rate and whether using a 25 G needle would have advantages given its lower rate of failure [3].…”

mentioning

confidence: 99%

“…Kathirgamanathan and Hawkins acknowledge Tuffier's line is a variable landmark which often corresponds to a higher than estimated vertebral space and recognise the importance of choosing a low vertebral interspace for spinal insertion [2]. We are concerned therefore that they chose to insert spinals one space above Tuffier's line in the first instance and two spaces above if unsuccessful.…”

mentioning

confidence: 99%

See 3 more Smart Citations

A reply

Kathirgamanathan¹,

Hawkins²

2007

Anaesthesia

View full text Add to dashboard Cite

Section: Emergency Anaesthesia At High Altitudesupporting

confidence: 76%

Section: A Replymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

A reply

Kathirgamanathan¹,

Hawkins²

2007

Anaesthesia

View full text Add to dashboard Cite

“…Anesthetics, analgesics, and tranquilizers potentially decrease the ventilatory drive and need to be used with caution. Benzodiazepines impair respiration at HA at doses that have insignifi cant effects on respiration at low altitude [89,90]. Similar results were demonstrated after 50 g alcohol at moderate altitude [91].…”

Section: Anesthesia Management At Hasupporting

confidence: 71%

Physiology and pathophysiology at high altitude: considerations for the anesthesiologist

2009

View full text Add to dashboard Cite

Millions of people live in, work in, and travel to areas of high altitude (HA). Skiers, trekkers, and mountaineers reach altitudes of 2500 m to more than 8000 m for recreation, and sudden ascents to high altitude without the benefits of acclimatization are increasingly common. HA significantly affects the human body, especially the cardiovascular and pulmonary systems, because of oxygen deprivation due to decreased ambient barometric pressure. Rapid ascents may lead to high-altitude diseases that sometimes have fatal consequences. Other factors, such as severe cold, dehydration, high winds, and intense solar radiation, increase the morbidity of patients at HA. Anesthesiologists working in or visiting areas of higher elevations should become familiar with the human physiology, altered pharmacology, and disease pattern of HA.

show abstract

Efficiency of the cross‐over design: an empirical estimation

Garcia-Esteban

Benet

Arnau³

et al. 2004

Statistics in Medicine

View full text Add to dashboard Cite

The aim of the present study is to estimate the relative efficiency of cross-over clinical trials as compared to the corresponding parallel designs. A MEDLINE 'full text' search covering years 2000-2003 over the word 'cross-over' identified 40 true cross-over studies with the parametric approach published in leading medical journals. A parallel design is expected to need, in order to achieve the same power, between 4 and 10 times more subjects than the corresponding cross-over design, meaning that cost of a parallel design can be between 2 and 5 times higher. There is a high proportion (18/40 = 45.0 per cent) of cross-over studies recently published in leading medical journals that, disregarding the CONSORT recommendations, does not provide estimates for the effect size and its standard error, hence, not allowing for the posterior use of the data in a meta-analysis.

show abstract

Effect of temazepam on ventilatory response at moderate altitude

Cited by 21 publications

References 4 publications

A reply

A reply

Physiology and pathophysiology at high altitude: considerations for the anesthesiologist

Efficiency of the cross‐over design: an empirical estimation

Contact Info

Product

Resources

About