Effect of temperature and reactant concentration on calcium phosphate precipitation

Brasil, Luisa Rodrigues; Rodrigues, Marcela Charantola; Hewer, Thiago L.R.; Fronza, Bruna Marin; Arana-Chavez, Victor E.; Vichi, Flávio Maron; Madsen, Henrik Breuning; Braga, Roberto Ruggiero

doi:10.1016/j.jcrysgro.2020.125909

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…The increase in temperature accelerated the molecular thermal motion, resulting in faster ion migration, thereby increasing the reaction rate, which led to the scale size gradually becoming smaller and finer . When the hydrolysis reaction was promoted at high temperatures, the hydrogen evolution along with it changed the growth direction of the calcium–phosphorus crystal nucleus from horizontal to inclined to vertical fibrous, which also make the coating structure more loose. At higher deposition temperatures, the grain nucleation process had anisotropy, and the growth rate of the grain in the axial direction was much higher than that in the radial direction, so the preferred orientation of the C -axis was presented, and the fibrous structures with a higher aspect ratio was obtained.…”

Section: Resultsmentioning

confidence: 99%

Effect of Strontium-Substituted Calcium Phosphate Coatings Prepared by One-Step Electrodeposition at Different Temperatures on Corrosion Resistance and Biocompatibility of AZ31 Magnesium Alloys

Xu,

Li,

Zhang

et al. 2023

ACS Biomater. Sci. Eng.

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As potential degradable biomaterials, magnesium (Mg) alloys have development prospects in the field of orthopedic load-bearing, whereas the clinical application has encountered a bottleneck due to a series of problems caused by its rapid corrosion. In this study, strontium-substituted calcium phosphate (CaP) coatings with different structures were prepared on the surface of the Mg matrix by a simple one-step electrodeposition method at different temperatures, which enhanced the poor corrosion resistance of the Mg matrix. The coated sample prepared at 65 °C reduced the corrosion current density by 3 orders of magnitude and increased the impedance by nearly 2 orders of magnitude compared with bare Mg alloy, thanks to its dense fibrous structure similar to that of natural bones. Although the coating composition varies with different preparation temperatures, CaP, as an inorganic component similar to natural bone, has good cytocompatibility. Doping the right amount of strontium, which is a trace element in human bones, is beneficial to stimulate osteoblast differentiation, inhibit the activity of osteoclasts, and induce the formation of bone tissues. This provides a new option for modifying the Mg alloy with CaP coatings as a base.

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Section: Resultsmentioning

confidence: 99%

Effect of Strontium-Substituted Calcium Phosphate Coatings Prepared by One-Step Electrodeposition at Different Temperatures on Corrosion Resistance and Biocompatibility of AZ31 Magnesium Alloys

Xu,

Li,

Zhang

et al. 2023

ACS Biomater. Sci. Eng.

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“…The precipitation with Fe was synthesized in an ice-water bath to prevent Fe segregation at high temperatures, whereas the other two were synthesized at room temperature . The coprecipitation of calcium phosphate at lower temperatures was more likely to generate CaHPO 4 ·2H 2 O, which has been proven by Brasil et al However, after calcination, all materials exhibited similar XRD spectra, and the precipitation converted to β-Ca 3 (PO 4 ) 2 . The reaction, as shown in Formula , happened under heating.…”

Section: Discussionmentioning

confidence: 95%

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Li,

Ma,

et al. 2023

ACS Biomater. Sci. Eng.

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There is an urgent demand for antibacterial bone grafts in clinics. Worryingly, the misuse and overuse of antibiotics accelerate the emergence of drug-resistant bacteria. Therefore, this study prepared a novel injectable bioceramic cement without antibiotics (FS-BCS), which showed good antibacterial properties by loading iron and strontium onto a matrix composed of brushite and calcium sulfate. The setting time, injectability, microstructure, antibacterial properties, anti-biofilm properties, and cytocompatibility of the novel bioceramic cement were evaluated thoroughly. The results showed that the material was highly injectable and antiwashout. The antibacterial tests revealed that FS-BCS inhibited the growth of 99.9% E. coli and S. aureus separately in the broth due to the synergistic effect of strontium and iron. Simultaneously, crystal violet and fluorescent staining tests revealed that the material could significantly inhibit the formation of E. coli and S. aureus biofilms. In addition, the co-incorporation of iron and strontium promoted the proliferation and migration of osteoblasts. Therefore, FS-BCS has good application potential in antibiotic-free anti-infection bone grafting using minimally invasive surgery.

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“…Octacalcium phosphate (Ca 8 (HPO 4 ) 2 (PO 4 ) 4 •5H 2 O, hereafter abbreviated as OCP) shares structural similarity with hydroxyapatite (Ca 3 (OH) 2 (PO 4 ) 6 , henceforth referred to as HA) and is reported to facilitate mineralized tissue formation as an initial precursor phase of HA [7][8][9]. OCP, under normal physiological conditions, is thermodynamically metastable with respect to HA, and it has been demonstrated that in vivo transformation of OCP to HA through hydrolysis takes place [10,11]. This conversion of OCP to HA has facilitated the study of OCP-based composites as bone scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Mineralization of Octacalcium Phosphate under Magnetic Field

He,

Xue,

Qian

et al. 2024

Crystals

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The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, which is crucial for directional growth of OCP crystals. The growth of OCP crystals was accelerated by the applied magnetic field, while OCP crystals generated in the presence of a magnetic field exhibited increased length and width of oriented growth. This study provides valuable insights into the influence of mineralization factors in bioprocessing-inspired manufacturing processes.

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Effect of temperature and reactant concentration on calcium phosphate precipitation

Cited by 5 publications

References 48 publications

Effect of Strontium-Substituted Calcium Phosphate Coatings Prepared by One-Step Electrodeposition at Different Temperatures on Corrosion Resistance and Biocompatibility of AZ31 Magnesium Alloys

Effect of Strontium-Substituted Calcium Phosphate Coatings Prepared by One-Step Electrodeposition at Different Temperatures on Corrosion Resistance and Biocompatibility of AZ31 Magnesium Alloys

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Mineralization of Octacalcium Phosphate under Magnetic Field

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