1996
DOI: 10.1039/ft9969200439
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Effect of temperature on crystal growth and crystal properties of paracetamol

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Cited by 32 publications
(39 citation statements)
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“…Firstly, the simulated and experimental desupersaturation curves can be compared, as shown in Figs. [8][9][10][11]. It can be seen from these figures that the model predictions for solution concentration are in good agreement with the experimental data, with an average and maximum error in the residuals, calculated using Eq.…”
Section: Accuracy Of Numerical Modelsupporting
confidence: 73%
See 1 more Smart Citation
“…Firstly, the simulated and experimental desupersaturation curves can be compared, as shown in Figs. [8][9][10][11]. It can be seen from these figures that the model predictions for solution concentration are in good agreement with the experimental data, with an average and maximum error in the residuals, calculated using Eq.…”
Section: Accuracy Of Numerical Modelsupporting
confidence: 73%
“…Two methods for the estimation of crystal growth rate kinetics are commonly described in the literature, namely single crystal growth studies and seeded desupersaturation experiments. Single crystal studies have been previously conducted on paracetamol, investigating the effects of supersaturation [6,7], temperature [8] and pH value [9], but only for aqueous solutions. Isothermal seeded batch experiments have been conducted for paracetamol and acetone-water mixtures, with non-linear optimisation utilised to evaluate the parameters of a power law expression to describe the growth rate, as a function of supersaturation, from the experimental desupersaturation curves [10].…”
Section: Introductionmentioning
confidence: 99%
“…Shekonov et al [3] studied the growth behavior of paracetamol at 47°C and 3°C. They have reported that (001) face dominates at 3°C whereas the (110) face dominates at 47°C.…”
Section: Introductionmentioning
confidence: 99%
“…5.18a). 73 This is a remarkable point as the morphology of paracetamol crystals also affects the industrial processing. For the monoclinic form, the experimental prismatic-to-plate-like morphology is well known (Fig.…”
Section: Paracetamolmentioning
confidence: 99%