The hardware and software designed in the traditional supply chain system lack cooperation in the transmission process, have low efficiency, and lead to a large amount of information distortion.In response to this problem, this paper proposes an intelligent supply chain information system based on the Internet of Things technology. The research focuses on the hardware and software of the system. The hardware part consists of the embedded processor CS89712, Flash7861 memory, Ethernet, touch screen, and LCD (Liquid Crystal Display). The software system is based on asymmetric information theory design and is divided into signal acquisition, input signal detection, interference signal processing, and power signal output. The experimental results show that it is compared with the traditional supply chain information system. The designed system seamlessly integrates the hardware and software components to achieve maximum information supply in the shortest amount of time. The power supply capacity is four times that of the traditional system, and the node coverage is high. When the number of data nodes is 120, the traditional supply chain system is basically unable to supply, but the supply accuracy of the intelligent supply chain is still as high as 48%. The research in this paper has certain guiding significance for intelligent technology development, supply chain system design, and enterprise information exchange.