Effect of TEOA on the Process of Photopolymerization at 532 nm and Properties of Nanogels

Peng, Yuanyuan; Wang, Zhipeng; Peña, Jhair; Guo, Zhiming; Xing, Jinfeng

doi:10.1111/php.13505

Cited by 6 publications

(3 citation statements)

References 65 publications

(63 reference statements)

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“…It was suggested that the increase in the molar ratios of activated phenylboronic acid groups from pba‐ePL or hydroxyl groups from tannic acid would cause less efficient crosslinking and decrease the crosslinking degree, leading to larger NGs. [ 25 ] Thus, NGs at the moderate P/T ratios of 5/1 and 10/1 were chosen in the subsequent experiment. In addition, all NGs exhibited negative zeta potentials from −16 to −20 mV (Figure 1i).…”

Section: Resultsmentioning

confidence: 99%

Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies

Xie,

Li,

Cao

et al. 2024

Adv Healthcare Materials

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Intracellular bacteria are the major cause of serious infections including sepsis and peritonitis, but face great challenges on fighting against the stubborn intracellular small colony variants (SCVs). Herein, we have developed nanogels (NGs) to destroy both planktonic bacteria and SCVs and eliminate excessive inflammations for peritonitis and sepsis therapies. Free gentamicin (GEN) and hydroxyapatite nanoparticles (NPs) with GEN loading and mannose grafts (mHAG) were inoculated into ε‐polylysine NGs to obtain NG@G1‐mHAG2 through crosslinking with phenylboronic acid and tannic acid. The H2O2 consumption after reaction with phenylboronic esters and the elimination of free radicals by tannic acid alleviate the escalated inflammatory status to promote sepsis therapy. After mannose‐mediated uptake into macrophages, the acid‐triggered degradation of mHAG NPs generates Ca2+ to destabilize lysosomes and the efficient lysosomal escape leads to reversion of hypometabolic SCVs into normal phenotype and their sensitivity to GEN. In a peritonitis mouse model, NG@G1‐mHAG2 treatment provides strong and persistent bactericidal effects against both extracellular bacteria and intracellular SCVs and extends survival of peritonitis mice without apparent hepatomegaly, splenomegaly, pulmonary edema and inflammatory cell infiltration. Thus, this study demonstrates a concise and versatile strategy to eliminate SCVs and relieve inflammatory storms for peritonitis and sepsis therapies without infection recurrence.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies

Xie,

Li,

Cao

et al. 2024

Adv Healthcare Materials

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“…For example, Bakó prepared nanogels using methacrylic acid poly-γ-glutamic nanoparticles loading antibiotic drug ampicillin by visible (blue) light-initiated photopolymerization, and the release kinetics showed the controlled and efficient release behaviors (Bakó et al, 2016). Notably, our lab has also developed some strategies on the preparation of nanogels through laser photopolymerization, which is related with the investigation of the initiating system, polymerization mechanism and biomedical applications (Li J. et al, 2021;Liu et al, 2021;Peng et al, 2021;Wang et al, 2021). Specifically, Wang chose biocompatible polyethylene glycol diacrylate (PEGDA) as a monomer and ultrasmall nanogels with around 30 nm in size were prepared successfully through surfactant-free photopolymerization at 532 nm.…”

Section: Free Radical Polymerizationmentioning

confidence: 99%

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Gao

Kang

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, the exploration of tumor microenvironment has provided a new approach for tumor treatment. More and more researches are devoted to designing tumor microenvironment-responsive nanogels loaded with therapeutic drugs. Compared with other drug carriers, nanogel has shown great potential in improving the effect of chemotherapy, which is attributed to its stable size, superior hydrophilicity, excellent biocompatibility, and responsiveness to specific environment. This review primarily summarizes the common preparation techniques of nanogels (such as free radical polymerization, covalent cross-linking, and physical self-assembly) and loading ways of drug in nanogels (including physical encapsulation and chemical coupling) as well as the controlled drug release behaviors. Furthermore, the difficulties and prospects of nanogels as drug carriers are also briefly described.

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“…[5][6][7][8] Many kinds of cross-linked host matrices have been reported, which are a mixture of at least two active substances, such as epoxy-amine, epoxy-thiol, isocyanate-alcohol, orthoester-anhydride, and thiol-allyl. [9][10][11][12][13][14] Compared with other cross-linked systems, epoxy-amine has excellent mechanical properties and low volume shrinkage, which is very important for millimeter-thick media in holographic data storage. However, high cross-linking density of epoxyamine matrices sacrificed the diffusivity of monomers, resulting in blurry grating fringes of allyl/epoxy-amine-based photopolymers, which limited their further applications.…”

Section: Introductionmentioning

confidence: 99%

Improving performance oftwo‐stagephotopolymers for volume holographic recording by fluorinatedepoxy‐amine cross‐linkedmatrices

Zhang

Zhao

Zhang

et al. 2022

J of Applied Polymer Sci

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Host matrices play an important role in the volume holographic gratings formation of photopolymers. In this study, a series of fluorinated epoxy resin (FTGE) with low refractive index (1.44-1.46) are synthesized and characterized by nuclear magnetic resonance spectra ( 1 H NMR, 19 F NMR) and fourier transform infrared spectra (FTIR). Fluorinated epoxy-amine cross-linked matrices are formed at room temperature and their thermal polymerization properties are investigated through real-time FTIR and thermogravimetric analyses (TGA). Using the fluorinated epoxy-amine as host matrices, holographic photopolymers are fabricated. The influence of different kinds (Prop-FTGE, Buta-FTGE, and Penta-FTGE) and weight ratios (0%, 8%, 16%, and 23%) of FTGEs on holographic performances of the photopolymers are explored. The results show that the sample with 23% Prop-FTGE has the most excellent holographic optical characteristics. 0.5 mm thick sample with 23% Prop-FTGE reaches 91% diffraction efficiency within 80 mJ/cm 2 exposure dosage, and gets a 2000 lp/ mm Bragg volume grating with 0.24 angular selectivity. Meanwhile, under a single pulse exposure mode (150-200 ps pulse width, 25 mJ/cm 2 exposure dosage), a grating with 4.4% diffraction efficiency is obtained, which proves the ultrafast response and recording capability of the sample.

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Effect of TEOA on the Process of Photopolymerization at 532 nm and Properties of Nanogels

Cited by 6 publications

References 65 publications

Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies

Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Improving performance oftwo‐stagephotopolymers for volume holographic recording by fluorinatedepoxy‐amine cross‐linkedmatrices

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