Effect of testing for cancer on cancer- or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE

Abstract

Search methods The Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, CENTRAL, MEDLINE, Embase and CINAHL databases and World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov trials registers to 11 July 2018. We also undertook reference checking to identify additional studies. Selection criteria Randomised and quasi-randomised trials in which people with an unprovoked VTE were allocated to receive specific tests for identifying cancer or clinically indicated tests only were eligible for inclusion. Primary outcomes included all-cause mortality, cancer-related mortality and VTE-related mortality. Data collection and analysis Two review authors independently selected studies, assessed risk of bias and extracted data. We resolved any disagreements by discussion. E ect of testing for cancer on cancer-or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE (Review)

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society

“…Although (extensive) screening for cancer leads to an earlier cancer diagnosis, evidence that screening reduces cancer-related morbidity or mortality is lacking. 11 Extensive imaging-based screening with chest CT imaging, abdominal CT imaging, and/or 18-fluorodeoxyglucose positron emission tomography/CT imaging may further increase the number of cancers detected at VTE diagnosis but should be avoided, since the survival benefit of such an approach has never been demonstrated, and at the same time it carries the considerable costs and risks of invasive tests, false-positive findings, and overdiagnosis.…”

Kidney Disease and Cancer Risk in Patients with Venous Thromboembolism: What Does It Mean for Clinical Practice?

“…Clearly, we cannot use an observational study to speculate on cause-and-effect relationships (in whatever direction) in the triangle 'kidney disease-VTE-cancer'. Moreover, and importantly, the present study does not challenge the unanimous, evidence-based (20) recommendations of scientific societies and guidelines against extensive cancer screening This article is protected by copyright. All rights reserved.…”

Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale

“…13 With additional diagnostic workup, occult cancer is identified in one out of every 20 patients within a year of unprovoked VTE diagnosis, though there is insufficient evidence for screening all patients with unprovoked VTE for occult cancer to reduce cancer-and VTE-related morbidity and mortality. 14,15 However, our patient's significant clot burden, cognitive decline, and presence of PFO warranted further diagnostic workup for occult cancer.…”