Effect of Tetrabenazine on the Afferent Pathways of the Central Nervous System

Takagi, Hiroshi; Ishida, Ryuichi

doi:10.1254/jjp.14.94

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…The results obtained in the present experiment was approximately same as those which have been described in the previous paper (2).…”

Section: Effects Of Tetrabenazinesupporting

confidence: 92%

“…The authors have recently ascertained that the sites of action of tetrabenazine are similar to those of morphine except their effects on the recruiting response (2) .…”

Section: Discussionmentioning

confidence: 99%

“…The spontaneous EEG of unanesthetized rabbits restrained stereotaxically was classified into three patterns which were fully described in the previous paper (2) c) Mixed pattern : the alert pattern and the resting pattern appear alternatively at the interval of several seconds to several minutes.…”

Section: The Spontaneous Eeg Of Unanesthetized and Non-curarized Rabbmentioning

confidence: 99%

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Antagonism by Tetrabenazine of the Depressive Effects of Morphine on the Central Nervous System

Takagi

Ishida

1965

Japanese Journal of Pharmacology

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The authors have reported in the previous papers that tetrabenazine antagonizes morphine analgesia in mice (1) and that it has depressive effects on some afferent pathways in the central nervous system in rabbits and cats, like those of morphine (2). The questions arise whether the antagonistic effect by tetrabenazine of the central effects of morphine can be recognized in other species besides mice, whether all of the depressive actions of morphine on the afferent pathways of the central nervous system are suppressed by the tetrabenazine pretreatment, and whether tetrabenazine may owe its antagonistic action against morphine to its ability to deplete the catecholamines and serotonin levels in the brain.The purpose of this study was to investigate these questions using the electro physiological techniques. METHODSA total of 48 male albino rabbits weighing from 2.5 to 3.0 kg were employed in the EEG experiments and 15 adult male cats weighing from 2.5 to 3.0 kg were used for the experiments of evoked potentials.The methods of both experiments were exactly similar to those described in the previous paper (2). The drugs used in the present experiments were tetrabenazine met hanesulphonate, morphine hydrochloride and dl-3,4-dihydroxyphenylalanine (DOPA), all of which were administered by the intravenous route. RESULTS1. The spontaneous EEG of unanesthetized and non-curarized rabbits restrained stereotaxicallyThe spontaneous EEG of unanesthetized rabbits restrained stereotaxically was classified into three patterns which were fully described in the previous paper (2). The outline of these patterns are as follows :

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“…The results obtained in the present experiment was approximately same as those which have been described in the previous paper (2).…”

Section: Effects Of Tetrabenazinesupporting

confidence: 92%

“…The authors have recently ascertained that the sites of action of tetrabenazine are similar to those of morphine except their effects on the recruiting response (2) .…”

Section: Discussionmentioning

confidence: 99%

Section: The Spontaneous Eeg Of Unanesthetized and Non-curarized Rabbmentioning

confidence: 99%

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Antagonism by Tetrabenazine of the Depressive Effects of Morphine on the Central Nervous System

Takagi

Ishida

1965

Japanese Journal of Pharmacology

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“…The electroencephalographic studies of reserpine, decaserpine and tetrabenazine have been described elsewhere (5)(6)(7). Reserpine and decaserpine produced a biphasic response in unanesthetized rabbit.…”

mentioning

confidence: 99%

ELECTROENCEPHALOGRAPHIC STUDIES OF XYLOPININE, 2,3,10,11-TETR AMETHOX Y-5,6-13,13a-TETRAH YDRO-8-DIBENZO(a-g) QUINOLIZINE CITRATE IN RABBIT

Nakanishi

1964

Japanese Journal of Pharmacology

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Central effects of 3,4-dihydroxyphenylalanine and 5-hydroxy tryptophane on tetrabenazine pretreated rabbits with special reference to the possible role of catecholamine and serotonin in the brain

Satoh

Yamatsu

Kimura

et al. 1968

International Journal of Neuropharmacology

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Effect of Tetrabenazine on the Afferent Pathways of the Central Nervous System

Cited by 3 publications

References 19 publications

Antagonism by Tetrabenazine of the Depressive Effects of Morphine on the Central Nervous System

Antagonism by Tetrabenazine of the Depressive Effects of Morphine on the Central Nervous System

ELECTROENCEPHALOGRAPHIC STUDIES OF XYLOPININE, 2,3,10,11-TETR AMETHOX Y-5,6-13,13a-TETRAH YDRO-8-DIBENZO(a-g) QUINOLIZINE CITRATE IN RABBIT

Central effects of 3,4-dihydroxyphenylalanine and 5-hydroxy tryptophane on tetrabenazine pretreated rabbits with special reference to the possible role of catecholamine and serotonin in the brain

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