Effect of tetracycline on mineralization in cycloheximide-treated bonesin vitro

Kaitila, Ilkka

doi:10.1007/bf02062592

Cited by 19 publications

(2 citation statements)

References 33 publications

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“…In the laboratory the 5 ml suspensions of plaque (SP) were analysed as follows: 1. Turbidity -The bacterial cells and other insoluble particles suspended in the 5 ml SP were resuspended for one minute using vortex mixing and then read immediately at 420 Gray & Gallway (1968) modified by the addition of perchloric acid as described by Kaitila (1971). 3.…”

Section: Methodsmentioning

confidence: 99%

Spiramycin as a selective dental plaque control agent

J¹,

Johnson²,

Haq³

et al. 1979

J of Periodontal Research

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Spiramycin was tested as a chemotherapeutic plaque control agent. Sixty‐ three volunteers (29 experimental and 34 control) abstained from mechanical oral hygiene procedures for 11 weeks. The participants were divided randomly into exeperimental and control groupa and received, on a double blind basis, either 20–500 mg capsules of spiramycin or 20 capsules of placebo with directions to take 1 capsule 4 times a day for 5 days. At each examination visit intra‐oral photographs were taken, gingival and plaque indices recored, and plaque samples collected for laboratory study. In the experimental group there was a statistically significant decrease in plaque as measured by wet weight, turbidity, nitrogen, and carbogydrat parameters for at least 3 weeks. There was a significant decrease in the number of Streptococcus mutasn and S. sanguis in the plaque samples at weeks 1 and 3, but there was no detectable influence on the number of Gram‐negative organisms.

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Section: Methodsmentioning

confidence: 99%

Spiramycin as a selective dental plaque control agent

J¹,

Johnson²,

Haq³

et al. 1979

J of Periodontal Research

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“…We have previously shown that administration of the antibiotic oxytetracycline to young rats causes reduced mechanical strength of bone and skin (Engesaeter & Skar 1978) and possibly interferes with the cross-linking of collagen (Engesaeter et al 1980). Several in vitro studies (Kaitila 1971, West & Storey 1972 have indicated that tetracyclines exert their main effect on bone by inhibiting the calcification. In vivo studies, however, have provided confusing results (Bevelander et al 1960, Ogawa et al 1961, Harris et al 1968.…”

mentioning

confidence: 99%

Effects of Oxytetracycline on Mineralization of Bone in Young Rats

Engesæter

Underdal

Langeland

1980

Acta Orthopaedica Scandinavica

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The metabolism of minerals and collagen in young rats receiving oxytetracycline was studied by employing double-isotope techniques. The dosage of the antibiotic was adjusted to obtain plasma concentrations comparable with human therapeutic levels. Reduced mineralization and possibly increased resorption of bone were observed after oxytetracycline administration, whereas no effect on the rate of collagen synthesis could be detected.

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The teratogenic effects in rabbits of doxycycline, dissolved in polyvinylpyrrolidone, injected into the yolk sac

Claussen¹,

Breuer²

1975

Teratology

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A technique was developed for injecting agents into the yolk sac of rabbits to study their teratogenic effects. On the 9th day of gestation the rabbits were laparotomized during ether-oxygen narcosis. The test substance was injected into the yolk sacs in one horn of the uterus, and as control the corresponding solvent was injected into the other horn. On the 28th day of gestation the rabbits were killed, resorptions counted, and fetuses examined for malformations. Three series of studies were made: physiological saline; polyvinylpyrrolidone; and doxycycline dissolved in polyvinylpyrrolidone (DIP). The rate of resorptions and malformations significantly increased after injection of Vibravenos. As polyvinylpyrrolidone was not teratogenic it is concluded that the teratogenic effects of DIP were probably caused by doxycycline.

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Effect of tetracycline on mineralization in cycloheximide-treated bonesin vitro

Cited by 19 publications

References 33 publications

Spiramycin as a selective dental plaque control agent

Spiramycin as a selective dental plaque control agent

Effects of Oxytetracycline on Mineralization of Bone in Young Rats

The teratogenic effects in rabbits of doxycycline, dissolved in polyvinylpyrrolidone, injected into the yolk sac

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