Effect of the -148C/T, 448G/A, and -854G/A Polymorphisms of the β-Fibrinogen Gene on the Risk of Ischemic Stroke in Chinese Population

Wu, Guangliang; Cai, Haiyan; Cai, Hao; Zhao, Chen; Tan, Lianjiang; Qi, Huitao; Cai, Yefeng

doi:10.1016/j.jstrokecerebrovasdis.2015.03.029

Cited by 9 publications

(9 citation statements)

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“…Gao et al perform a meta-analysis about whether genetic variants of AGT gene are related to IS on the basis of previous studies, the results show the significant relevance of AGT M235T, T174M polymorphisms with the susceptibility to IS in the Chinese Han population [24]. Wu et al also prove that β-fibrinogen gene polymorphisms possibly contribute to the risk of IS development in the Chinese Han population [25]. In addition, COX , MMP , CCM , and IL relative genes are identified to involve in the pathology of IS.…”

Section: Discussionmentioning

confidence: 99%

The Association Between the Genetic Variants of the NOTCH3 Gene and Ischemic Stroke Risk

Yuan

Dong

2016

Med Sci Monit

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BackgroundIschemic stroke (IS) is a leading cause of disability and death and NOTCH3 as a gene related with cardiac-cerebral vascular disease plays a vital role in IS development. However, the reports about the effect of genetic variants in NOTCH3 gene on IS are still few.Material/MethodsIn order to explore the association between NOTCH3 polymorphisms and IS, 134 patients with IS and 115 controls were enrolled in this case-control study. Polymerase chain reaction was used to do the genotyping of polymorphisms. The χ2 test was performed to evaluate Hardy-Weinberg equilibrium (HWE) in the control group and calculate odds ratio (OR) with corresponding 95% confidence interval (CI) which represented the association intensity of NOTCH3 gene polymorphisms and IS risk.ResultsThe genotype frequencies in the control group all confirmed to HWE. TT genotype of 381C>T was associated significantly with IS risk (OR=2.441, 95%CI=1.021–5.837). TC, CC mutant genotypes of 1735T>C had higher frequencies in cases than controls and the difference was significant (P=0.013, 0.041); further, its C allele also increased 0.722 times risk in the case group than controls (OR=1.722, 95%CI=1.166–2.541).ConclusionsNOTCH3 381C>T and 1735T>C polymorphisms were associated with IS and might be the risk factors for IS development, but not NOTCH3 605C>T polymorphism.

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Section: Discussionmentioning

confidence: 99%

The Association Between the Genetic Variants of the NOTCH3 Gene and Ischemic Stroke Risk

Yuan

Dong

2016

Med Sci Monit

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“…A meta-analysis which included 12 case-control studies involving 1,536 cases and 1,329 control subjects demonstrated that 148 CT polymorphism of the β-fibrinogen gene is a susceptibility marker for risk of IS [20]. Another meta-analysis which involved 32 independent studies with 4,311 cases and 4,124 controls demonstrated that 148 CT polymorphism of β-fibrinogen contributes to susceptibility to IS [11]. …”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the C148T polymorphism of β-fibrinogen is associated with an increased plasma fibrinogen level in both men and women [8,9,10]. A meta-analysis of 20 studies in a Chinese population including 2,561 cases and 2,402 controls has shown a significant association between C148T gene polymorphism and risk of IS with a pooled OR of 1.56 (95% CI 1.39-1.75) [11]. However, these studies were confined to a single population; therefore, studies with large sample sizes from different populations are required.…”

Section: Introductionmentioning

confidence: 99%

Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study

Kumar

Misra

Kumar

et al. 2016

Pulse

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Background and Purpose: Stroke is a multifactorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between β-fibrinogen C148T (rs1800787) gene polymorphism and susceptibility to ischemic stroke (IS) in a North Indian population. Methods: In the present case-control study, genotyping was performed using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method on 250 IS patients and 250 age- and sex-matched controls. Frequency distributions of genotypes and alleles were compared between the cases and controls by conditional logistic regression. Results: Hypertension, diabetes, dyslipidemia, low socioeconomic status, and family history of stroke were found to be independent risk factors for IS. The mean age of the cases and controls was 52.83 ± 12.59 and 50.97 ± 12.70 years, respectively. Multivariate logistic regression analysis showed an independent association between β-fibrinogen C148T (rs1800787) polymorphism and risk of IS in dominant (OR = 2.19; 95% CI 1.23-3.90; p = 0.007) and allelic (OR = 1.66; 95% CI 1.19-2.33; p = 0.002) models. Based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, an independent association of small vessel disease with risk of IS was observed in the dominant (OR = 2.09; 95% CI 1.10-3.96; p = 0.02) and allelic (OR = 1.75; 95% CI 1.12-2.75; p = 0.01) models, and a significant association of cardioembolic stroke with risk of IS was seen in the allelic model (OR = 2.11; 95% CI 1.07-4.17; p = 0.02). All the genotype frequencies observed were in accordance with Hardy-Weinberg equilibrium in both cases and controls. Conclusion: The findings of the present study suggest that polymorphism in the C148T position of the β-fibrinogen gene might be a risk factor for IS mainly for the small vessel disease stroke subtype in a North Indian population. Further, large prospective studies are required to confirm these findings.

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“…Fibrinogen, as a vascular risk factor, can be used as a biomarker for ischemic atherothrombotic stroke, coronary heart disease, peripheral arterial disease, and atherosclerosis. [3][4][5][6][7] Evidence from a wide range of sources has suggested that people with higher Fg levels also have an increased risk of dementia, 8,9 and Fg level is positively correlated with the risk of AD and VaD. 8 Therefore, Fg, as a common vascular risk factor, may contribute to VaD and AD, and both forms of dementia seem to have similar pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 In addition, polymorphisms in the fibrinogen b-chain gene (FGB) are strongly associated with plasma Fg level. 6,12 Thus, FGB gene polymorphisms might contribute to susceptibility of dementia by affecting plasma Fg level.…”

Section: Introductionmentioning

confidence: 99%

Relationship between fibrinogen level and its regulatory gene with Alzheimer’s disease and vascular dementia

Sun

Liu

et al. 2020

J Int Med Res

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Objective: Several investigations have shown that the level of fibrinogen (Fg) is associated with the susceptibility to dementia and is usually affected by polymorphisms in its gene. Our study aimed to investigate the relationship between Fg level and the fibrinogen b (FGB) À148C/T gene polymorphism in patients with Alzheimer's disease (AD) and vascular dementia (VaD). Methods: The study included 64 AD patients, 72 VaD patients, and 56 healthy controls (HC). Plasma Fg level was detected by turbidimetry. Among the participants, 64 AD patients, 52 VaD patients, and 56 HC underwent FGB À148C/T polymorphism analysis using restriction fragment length polymorphism-PCR. Results: Plasma Fg was significantly higher in AD and VaD groups than in HC. The AD and VaD patients with FGB À148 TT genotype had significantly higher plasma Fg than those with CC or CT genotypes. The distribution of CC and CTþTT genotypes differed in the three groups, with the frequency of CTþTT genotypes being higher in AD patients than in the HC group. Conclusions: Plasma Fg level was significantly correlated with AD and VaD and related to the À148C/T polymorphism of FGB. The TTþCT genotypes and the distribution frequency of the T allele may be related to AD.

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Effect of the -148C/T, 448G/A, and -854G/A Polymorphisms of the β-Fibrinogen Gene on the Risk of Ischemic Stroke in Chinese Population

Cited by 9 publications

References 40 publications

The Association Between the Genetic Variants of the NOTCH3 Gene and Ischemic Stroke Risk

The Association Between the Genetic Variants of the NOTCH3 Gene and Ischemic Stroke Risk

Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study

Relationship between fibrinogen level and its regulatory gene with Alzheimer’s disease and vascular dementia

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