Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat

Sivarao, Digavalli V.; Newberry, Kimberly; Lodge, Nicholas J.

doi:10.1016/j.ejphar.2004.04.034

Cited by 29 publications

(19 citation statements)

References 23 publications

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“…Although analgesics attenuate distension-induced hypertensive response in conscious animals, our results showed a definite changes by DA-9701administration. And, according to report of Sivarao et al ,36 the myoelectrical response was different between the WKY rats and the SD strain, but the cardiovascular changes to distension were about the same in each strain.…”

Section: Discussionmentioning

confidence: 70%

“…Maternal separation changed the expression of the 5-HT 1A receptor in the amygdala, hippocampus, and prefrontal cortex 33–35. Buspirone, a 5-HT 1A receptor partial agonist, attenuated the colorectal disension-induced changes in MAP and abdominal withdrawal response, in anesthetized and conscious rats, respectively 36. Moreover, in another study, sumatriptan suppressed both inflammatory and noninflammatory visceral pain, most likely through peripheral 5HT 1B/D receptors 37.…”

Section: Discussionmentioning

confidence: 93%

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Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

et al. 2014

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Background/AimsDA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Co-rydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model.MethodsMale Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6 weeks after birth, CRD was applied to these rats with a pressure of 20 to 90 mm Hg, and changes in the mean arterial pressure (MAP) were measured at baseline (i.e., without any drug administration) and after the administration of different doses of DA-9701.ResultsIn the absence of DA-9701, the MAP changes after CRD were significantly higher in the CI group than in the control group at all applied pressures. In the control group, MAP changes after CRD were not significantly affected by the administration of DA-9701. In the CI group, however, the administration of DA-9701 resulted in a significant decrease in MAP changes after CRD. The administration of DA-9701 at a dose of 1.0 mg/kg produced a more significant decrease in MAP changes than the 0.3 mg/kg dose.ConclusionsThe administration of DA-9701 resulted in a significant increase in pain threshold in rats with CRD-induced visceral hypersensitivity.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 93%

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

et al. 2014

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“…For example, buspirone, a partial 5-HT 1 receptor agonist, with anxiolytic activity displays analgesic effect in the CRD-induced visceral pain model in rats (Sivarao et al, 2004). Similarly, robalzotan tartrate monohydrate (AZD7371), a selective competitive 5-HT 1A receptor antagonist, initially developed as a potential treatment for depression and anxiety disorders significantly reduces the visceromotor response to CRD in rats (Lindström et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Stress and visceral pain: From animal models to clinical therapies

Larauche

Mulak

Taché

2012

Experimental Neurology

181

207

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Epidemiological studies have implicated stress (psychosocial and physical) as a trigger of first onset or exacerbation of irritable bowel syndrome (IBS) symptoms of which visceral pain is an integrant landmark. A number of experimental acute or chronic exteroceptive or interoceptive stressors induce visceral hyperalgesia in rodents although recent evidence also points to stress-related visceral analgesia as established in the somatic pain field. Underlying mechanisms of stress-related visceral hypersensitivity may involve a combination of sensitization of primary afferents, central sensitization in response to input from the viscera and dysregulation of descending pathways that modulate spinal nociceptive transmission or analgesic response. Biochemical coding of stress involves the recruitment of corticotropin releasing factor (CRF) signaling pathways. Experimental studies established that activation of brain and peripheral CRF receptor subtype 1 plays a primary role in the development of stress-related delayed visceral hyperalgesia while subtype 2 activation induces analgesic response. In line with stress pathways playing a role in IBS, non-pharmacologic and pharmacologic treatment modalities aimed at reducing stress perception using a broad range of evidence-based mind-body interventions and centrally-targeted medications to reduce anxiety impact on brain patterns activated by visceral stimuli and dampen visceral pain.

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“…Abdominal withdrawal response was graded by an observer blinded to treatment or by recording the associated myoelectrical activity (see below). Visual quantification of the abdominal response was made on a scale of 0 to 3 as described previously (Sivarao et al, 2004). To minimize error, an average from three consecutive trials was recorded for each animal.…”

Section: Methodsmentioning

confidence: 99%

Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca²+-Activated K⁺(Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception

Sivarao

Newberry²,

Langdon³

et al. 2005

J Pharmacol Exp Ther

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We evaluated the effects of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), an opener of large conductance Ca 2ϩ -activated potassium (maxi-K) channels, on normal and stress-exacerbated colonic motility and visceral nociception in the rat. Fecal output was employed as an index of motility. Visceral nociception, in response to intracolonic balloon distension (10 -90 mm Hg; 30 s duration), was evaluated using one of three indices: change in blood pressure, abdominal withdrawal, or myoelectrical activity. BMS-223131 (2, 6, or 20 mg/kg i.p.) produced a small but dose-dependent and significant reduction in cumulative 24-h fecal output. Fecal output in response to stress (1-h restraint plus bursts of air to the face) was markedly inhibited by BMS-223131, and moisture content was significantly reduced. With regard to visceral pain, the transient and distentiondependent reduction in arterial pressure in anesthetized animals was inhibited by BMS-223131 in a dose-dependent manner. Distension-induced abdominal withdrawal in conscious rats was also dose-dependently attenuated by BMS-223131. BMS-223131 at a dose of 20 mg/kg markedly attenuated the increase in myoelectrical activity evoked by balloon distention in conscious animals. BMS-223131 was also evaluated in viscerally hypersensitive rats (sensitized as neonates by intracolonic mustard oil) where it produced a robust dose-dependent attenuation of the abdominal withdrawal response. Compared with naive animals, BMS-223131 was more potent in the sensitized animals. Thus, BMS-223131 effectively reduced stressinduced colonic motility and visceral nociception supporting the potential utility of maxi-K channel openers for the treatment of bowel disorders involving dysfunctional motility and visceral sensitivity.

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Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat

Cited by 29 publications

References 23 publications

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Stress and visceral pain: From animal models to clinical therapies

Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca²+-Activated K⁺(Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception

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Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat

Cited by 29 publications

References 23 publications

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Stress and visceral pain: From animal models to clinical therapies

Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+(Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception

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Resources

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Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca²+-Activated K⁺(Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception