Effect of the addition of a fugitive salt on electrospinnability of poly(ε-caprolactone)

Moghe, A. K.; Hufenus, Rudolf; Hudson, Samuel M.; Gupta, Bhupender S.

doi:10.1016/j.polymer.2009.04.063

Cited by 89 publications

(72 citation statements)

References 42 publications

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“…PCL was dissolved in glacial acetic acid/pyridine (100:1) to obtain a 15% w/v solution. Fibrous matrices were produced by electrospinning as previously reported (Moghe et al 2009, Guex et al 2012. Briefly, the apparatus consisted of a positive (applied to the needle) and a negative (applied to the collector) voltage supply source (aip Wild AG, Oberglatt, Switzerland) that maintained an electrical field.…”

Section: Substrate Production and Characterizationmentioning

confidence: 99%

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

et al. 2013

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Engineered muscle constructs provide a promising perspective on the regeneration or substitution of irreversibly damaged skeletal muscle. However, the highly ordered structure of native muscle tissue necessitates special consideration during scaffold development. Multiple approaches to the design of anisotropically structured substrates with grooved micropatterns or parallel-aligned fibres have previously been undertaken. In this study we report the guidance effect of a scaffold that combines both approaches, oriented fibres and a grooved topography. By electrospinning onto a topographically structured collector, matrices of parallel-oriented poly(ε-caprolactone) fibres with an imprinted wavy topography of 90 μm periodicity were produced. Matrices of randomly oriented fibres or parallel-oriented fibres without micropatterns served as controls. As previously shown, un-patterned, parallel-oriented substrates induced myotube orientation that is parallel to fibre direction. Interestingly, pattern addition induced an orientation of myotubes at an angle of 24• (statistical median) relative to fibre orientation. Myotube length was significantly increased on aligned micropatterned substrates in comparison to that on aligned substrates without pattern (436 ± 245 μm versus 365 ± 212 μm; p < 0.05). We report an innovative, yet simple, design to produce micropatterned electrospun scaffolds that induce an unexpected myotube orientation and an increase in myotube length.

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Section: Substrate Production and Characterizationmentioning

confidence: 99%

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

et al. 2013

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“…By combining the favourable intrinsic properties of the polymer PCL with the unique characteristics of a nanofibrous structure a promising material for biomedical applications can be obtained [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…However, obtaining bead-free fibres with diameters in the nanoscale range appeared to be difficult [4,6,[9][10][11][12][13][14][15]. For medical applications it is nevertheless essential to have fibre diameters in this range in order to mimic the natural extra cellular matrix morphology and thus to promote optimal cell growth [16].…”

Section: Introductionmentioning

confidence: 99%

“…Chloroform is most often applied as solvent for electrospinning PCL but produces rather microfibres instead of nanofibres as the diameters are typically 3 to 5 µm [15,17]. Other relatively highly toxic solvents such as dimethylformamide (DMF), tetrafluoroethylene, methylene chloride, dichloroethane and pyridine have been reported as well [4,6,[18][19][20][21][22]. Some of them allow for nanofibres with diameters in the nanoscale range but in none of the reported systems attention was given to the stability nor the reproducibility of the electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

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An alternative solvent system for the steady state electrospinning of polycaprolactone

Schueren

Schoenmaker

Kalaoğlu

et al. 2011

European Polymer Journal

243

139

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Polycaprolactone (PCL) is a biocompatible aliphatic polyester with many possible applications in the medical field. PCL nanofibres, produced by electrospinning, could provide new characteristics that are of interest for these applications. However, a key prerequisite is the ability to obtain bead-free fibres with diameters in the nanoscale range. At present the most commonly used solvent for electrospinning PCL is chloroform, but this only leads to fibres in the microscale range. Therefore various solvent systems were examined in this study.The innovative solvent mixture formic acid/acetic acid was found to allow for nanofibres with a diameter ten times smaller than chloroform. Moreover, steady state conditions could be obtained which thus allow electrospinning in a stable and reproducible way. Further it was noticed that the average fibre diameter decreased with decreasing polymer concentration while the diameter distribution decreased with increasing amount of formic acid. Also the humidity, an often overlooked yet important parameter, was noted to affect both diameter 2 characteristics. Generally it can be concluded that the solvent system formic acid/acetic acid could fill the gap in electrospinning PCL since it is readily able to produce uniform fibres in the nanoscale range.

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“…Os autores verificaram uma diminuição no diâmetro médio das fibras com a adição do cloreto de alumínio. Este comportamento também foi reportado por outros autores em outros sistemas [58][59][60][61][62] . Picciani et al observaram que a adição de um de polímero condutor altera significantemente as propriedades da solução e, consequentemente, das fibras formadas.…”

Section: Arranjo Experimentalunclassified

Eletrofiação de Polímeros em Solução: parte I: fundamentação TeÃ³rica

et al. 2012

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Resumo: A técnica de eletrofiação é conhecida desde a década de 1930, porém, somente com o advento das novas aplicações da nanotecnologia esta importante técnica foi re-descoberta. As potencialidades de nanofibras, de tamanhos da ordem de 50 a 500 nm e com extensão micrométrica, têm sido investigadas para diferentes materiais, com resultados promissores em diferentes aplicações. Nesta primeira parte, este trabalho de revisão propôs-se a detalhar as bases fundamentais do processo de eletrofiação. São descritas as influências das variáveis de processo, como campo aplicado, distância de trabalho, velocidade de rotação do coletor e de injeção da solução. Variáveis associadas ao sistema, como tipo de solvente e polímero de interesse, também são discutidas. Palavras-chave: Eletrofiação, polímeros, nanofibras, parâmetros do processo, parâmetros da solução. Electrospinning of Polymers in Solution. Part I: Theoretical FoundationAbstract: The electrospinning technique has been known since the 1930s, but only with the advent of new nanotechnology applications this technique was re-discovered and became important for production of nanomaterials. The potential for obtaining different nanofibers with sizes ranging from 50 to 500 nm and micrometer length has been investigated for different materials, with promising results in different applications. The first part of this review is aimed at describing the fundamentals of the electrospinning process. We describe the influence of process variables such as applied field, working distance, speed of rotation of the collector and solution injecting flow rate. The variables associated to this system, such as type of solvent and polymer of interest, are also discussed. Keywords: Electrospinning, polymers, nanofibers, process parameters, solution parameters. IntroduçãoNovas fronteiras na aplicação de polímeros têm sido recentemente investigadas, envolvendo a obtenção de novas moléculas precursoras, estruturas e arranjos moleculares em etapas de síntese e processamento [1,2] . Entre os tópicos de grande interesse, o processamento de materiais poliméricos em tamanhos nanométricos ganha constante atenção em função das novas propriedades associadas à escala nanométrica, bem como das possíveis novas aplicações para tais materiais [1,2] . Diferentes geometrias podem levar a diferentes propriedades e aplicações o que, neste aspecto, permite que trabalhos acerca do processamento destas nanoestruturas ganhem importância.Entre os formatos de maior interesse científico e tecnológico, nanofibras ou nanofios estão entre os mais estudados, dado o grande número de possíveis aplicações [2] . Em especial, o método de eletrofiação se mostra bastante conveniente para a produção destas nanoestruturas. Este método, inicialmente proposto por Formhal, em 1938 [3] foi redescoberto recentemente por Reneker e Doshi [4] e tem sido extensivamente estudado para a produção de diversos tipos de nanofibras ou nanofios de diferentes polímeros, como poli(vinilpirrolidona) [5] , poli(ácido lático) [6] , poli(álcool vi...

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Effect of the addition of a fugitive salt on electrospinnability of poly(ε-caprolactone)

Cited by 89 publications

References 42 publications

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

Anisotropically oriented electrospun matrices with an imprinted periodic micropattern: a new scaffold for engineered muscle constructs

An alternative solvent system for the steady state electrospinning of polycaprolactone

Eletrofiação de Polímeros em Solução: parte I: fundamentação TeÃ³rica

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