Effect of the administration of statins in non-cardiac critical disease

Ruiz-Bailén, Manuel; Pérez-Valenzuela, Jesús; Ferrezuelo-Mata, Álvaro; Obra-Cuadra, R.J.

doi:10.1016/s2173-5727(11)70015-7

Cited by 1 publication

(1 citation statement)

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“…These treatments, in 10-20% of patients, fail to normalize the hemodynamics of patients with septic shock, existing high probability that the cardiac output was diminished by SIMD. There is no known way to mitigate the SIMD, although it begins to consider the need to study the administration of a cardioprotective therapy to critically ill patients, which could have a special role for beta-blockers, inhibitors of the enzyme converting (ACE) inhibitors, calcium channel blockers and statins [ 196 ]. Nor is there consensus for the treatment of diastolic dysfunction in the SIMD, although the evidence in similar circumstances such as heart failure, also suggests that ACE inhibitors, antagonists of angiotensin-II receptor, and beta blockers have a potential benefit [ 197 ].…”

Section: Treatmentmentioning

confidence: 99%

Sepsis-induced Cardiomyopathy

Romero-Bermejo

Ruiz-Bailén²,

Gil-Cebrian³

et al. 2011

CCR

242

178

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Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both ventricles can dilate and diminish its ejection fraction, having less response to fluid resuscitation and catecholamines, but typically is assumed to be reversible within 7-10 days. In the last 30 years, It´s being subject of substantial research; however no explanation of its etiopathogenesis or effective treatment have been proved yet. The aim of this manuscript is to review on the most relevant aspects of the sepsis-induced myocardial dysfunction, discuss its clinical presentation, pathophysiology, etiopathogenesis, diagnostic tools and therapeutic strategies proposed in recent years.

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Section: Treatmentmentioning

confidence: 99%