Effect of the Ala12 Allele in the PPARγ-2 Gene on the Relationship Between Birth Weight and Body Composition in Adolescents: The AVENA Study

Labayen, Idoia; Moreno, Luís A.; Marti, Amelia; González‐Lamuño, Domingo; Wärnberǵ, Julia; Ortega, Francisco B.; Bueno, Gloria; Nova, Esther; Ruiz, Jonatan R.; Garagorri, J. M.; Martínéz, J. Alfredo; García‐Fuentes, Miguel; Bueno, Manuel

doi:10.1203/pdr.0b013e318156887a

Cited by 15 publications

(12 citation statements)

References 39 publications

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“…The follow-up of our study group will show whether the finding applies to Finnish children with PA. The results regarding the relationship between the minor Ala12 variant and birth measures have been contradictory [20,27,29,30]. The biggest studies on infants have shown no difference in birth measures concerning Pro12Ala polymorphism of PPARG [30], which is in line with our findings.…”

Section: Discussionsupporting

confidence: 90%

Polymorphism Pro12Ala of <i>PPARG</i> in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children

et al. 2010

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Background: The peroxisome proliferator-activated receptor-γ2 (PPARγ2) participates in the regulation of insulin sensitivity, and has connections to the GH-IGF system and ACTH-adrenal androgen axis. We hypothesized that PPARG Pro12Ala polymorphism leading to decreased receptor activity could contribute to the premature onset of adrenarche (PA). Methods: We performed a cross-sectional association study in 73 prepubertal children with PA and 97 age- and sex-matched healthy control children. Growth data, baseline hormone levels, and the values of oral glucose tolerance test (OGTT) were compared with PPARG genotypes. Results: We found no difference in the genotype distribution of PPARG between the PA and control children. The minor Ala12 variant was associated with lower current height SD scores (SDS) in the controls, but no similar association was seen in the PA children. Birth measures and current weight for height were equal between the genotype groups in both control and PA children. The Ala12 variant was associated with trends for a lower serum IGF-I level and lower serum insulin concentration at the 120-min time point of OGTT in control children. Conclusions: The Pro12Ala genotype of PPARG was not associated with PA. The minor Ala12 variant was associated with lower height SDS in healthy prepubertal children indicating its possible effects on growth.

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Section: Discussionsupporting

confidence: 90%

Polymorphism Pro12Ala of <i>PPARG</i> in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children

et al. 2010

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“…Adolescents carrying the Ala12 allele in the PPARg-2 gene lower birth weight was associated with lower lean body mass, whereas the associations in the Pro12Pro group disappeared after adjustment for potential confounders. 54 In summary, our findings suggest that subcutaneous fat mass in early childhood is at least partly established in fetal life and may have consequences for adiposity in later life. Follow-up studies are needed to assess whether subcutaneous fat mass in early childhood tracks to adulthood, and whether and to what extent the effects of parental, fetal anthropometrics and postnatal growth patterns on subcutaneous fat mass persist.…”

Section: Discussionmentioning

confidence: 59%

Tracking and determinants of subcutaneous fat mass in early childhood: the Generation R Study

Hokken-Koelega

Mook‐Kanamori

et al. 2008

Int J Obes

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Objectives: To examine the development and tracking of subcutaneous fat mass in the first 2 years of life and to examine which parental, fetal and postnatal characteristics are associated with subcutaneous fat mass. Design: This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. Subcutaneous fat mass was measured by skinfold thickness (biceps, triceps, suprailiacal, subscapular) at the ages of 1.5, 6 and 24 months in 1012 children. Information about parental, fetal and postnatal growth characteristics was collected by physical and fetal ultrasound examinations and questionnaires. Results: Normal values of subcutaneous fat mass are presented. Total subcutaneous fat mass was higher in girls than in boys at the age of 24 months (P ¼ 0.01). Subjects in the lowest and highest quartiles at the age of 6 months tended to keep their position in the same quartile at the age of 24 months (odds ratios 1.86 (95% confidence interval (CI) 1.3, 2.7)) and 1.84 (95% CI: 1.3, 2.6), respectively). Maternal height and weight, paternal weight, fetal weight at 30 weeks, birth weight and weight at the age of 6 weeks were each inversely associated with subcutaneous fat mass at the age of 24 months after adjustment for current weight at 24 months. Conclusion: This study shows for the first time that subcutaneous fat mass tends to track in the first 2 years of life. Furthermore, the results suggest that an adverse fetal environment and growth are associated with increased subcutaneous fat mass at the age of 24 months. Further studies are needed to examine whether these associations persist in later life.

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“…[26] The genetic determinism is decisive in influencing birth weight (ponderal index [PI]) corresponding to the length and adult metabolic disorders, and vice versa. [27,28] …”

Section: Introductionmentioning

confidence: 99%

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

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The aim of this study was to assess the impact of mothers’ and newborns’ fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother–newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029). There was a significant interaction effect between newborn and mother LEPR rs1137101 polymorphism on birth weight (P = 0.009) and BMI (P = 0.007). We noticed significantly increased birth weight and BMI in newborns carriers of AG + GG genotype, coming from mothers with AA genotype (P = 0.006). There was no evidence of significant interaction effect between newborn and mother FTO rs9939609 polymorphism on the studied anthropometrical data (P > 0.05). In addition, lower BMI scores (P = 0.042) were observed in newborns carriers of TT genotype whose mothers had AA + AT genotype. Lower MUAC scores (P = 0.041) were noticed in newborns carriers of AA + AT genotype whose mothers had AA + AT genotype for FTO rs9939609 gene polymorphism. Newborns carriers of the AG + GG genotype (P = 0.003) of LEPR rs1137101 coming from mothers with increased FMI (upper tertile) had significantly increased BMIs.Presence of the variant A allele of FTO rs9939609 polymorphism in mothers decreased BMI and MUAC in newborns. The impact of LEPR rs1137101 polymorphism on BMI and birth weight in newborns differed depending on the presence/absence of the dominant LEPR allele in mothers. In addition, we noticed that maternal FMI presented a significant positive effect on newborns’ BMI by changing the effect of LEPR rs1137101.We can conclude that mothers’ FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns’ BMI, therefore being involved in the newborns’ nutritional status and in the design of a potential protocol.

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Effect of the Ala12 Allele in the PPARγ-2 Gene on the Relationship Between Birth Weight and Body Composition in Adolescents: The AVENA Study

Cited by 15 publications

References 39 publications

Polymorphism Pro12Ala of <i>PPARG</i> in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children

Polymorphism Pro12Ala of <i>PPARG</i> in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children

Tracking and determinants of subcutaneous fat mass in early childhood: the Generation R Study

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

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