Effect of the alkyl substituent in NONOates derivatives on the reaction mechanism of NO liberation

Rangel-Galván, Violeta; Castro, María Eugenia; Pérez-Aguilar, José Manuel; Caballero, Norma A.; Meléndez, Francisco J.

doi:10.1007/s00214-019-2453-y

Cited by 1 publication

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[44,45] NO prodrugs, in which the terminal oxygen O 2 is linked to protecting groups, can selectively remove their protecting groups in the targeted organ or cell. [46] Thus, NO dosage can be centralized at a specific site, even if NO prodrugs are distributed throughout the body. Researchers designed protecting groups to decompose in the presence of specific enzymes to expose the active site and release NO.…”

Section: N-diazeniumdiolates (Nonoates) 21 Enzyme/enzyme Mimics-respo...mentioning

confidence: 99%

Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications

Liu

2022

Advanced Therapeutics

View full text Add to dashboard Cite

Nitric oxide (NO) serves a multitude of functions in human physiology and pathology, and therapeutic NO-releasing materials are vigorously developed for biomedical applications. Owing to its complex functions and its potential systemic effects, controllable NO release is desired for clinical applications. This review summarizes recent developments in the last five years in designing controllable NO-delivering platforms for treating diseases such as cancer, bacterial infection, cardiovascular diseases, wounds, and eye diseases, with a focus on the most commonly used NO donors, including N-diazeniumdiolates, S-nitrosothiols, arginine, and N-nitrosoamines. The progress and success of NO delivery strategies are highlighted, and their limitations are also included. Moreover, the therapeutic mechanisms of NO in the diseases are summarized, along with the corresponding means of controlling NO release. Finally, the prospects and potential challenges regarding the development of NO gas therapy are described, with the hope of encouraging new research in this area.

show abstract

Section: N-diazeniumdiolates (Nonoates) 21 Enzyme/enzyme Mimics-respo...mentioning

confidence: 99%

Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications

Liu

2022

Advanced Therapeutics

View full text Add to dashboard Cite

show abstract

Effect of the alkyl substituent in NONOates derivatives on the reaction mechanism of NO liberation

Cited by 1 publication

References 17 publications

Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications

Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications

Contact Info

Product

Resources

About