Effect of the amino acid analog hadacidin on intracellular membrane flow and the cell surface in Dictyostelium discoideum

Kinsella, Brenda A.; Whitehead, Mark C.; Thomas, Him F.; Rossomando, Edward F.

doi:10.1111/j.1432-0436.1986.tb00389.x

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1988

1994

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Cited by 4 publications

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“…There are several reports on the inhibition of pinocytosis by hadacidin (Rossomando et al, 1981;Kinsella et al, 1986), vanadate (Klein et al, 1989), cyclohexamide (Gonzalez and Satre, 1991), methylene diphosphonate (Bof et al, 1992), etc., in Dictyostelium discoideum. Besides these Maeda and Kawamoto (1986) have shown that 50 pg/ml of cytochalasin B stimulates the pinocytic activity.…”

Section: Resultsmentioning

confidence: 99%

Pinocytic stimulation in Dictyostelium discoideum by γ‐benzene hexachloride

Raghuraman¹,

Chatterjee²

1994

Journal Cellular Physiology

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Pinocytic activity is greatly stimulated in gamma-BHC (gamma isomer of benzene hexachloride) treated, vegetative cells of Dictyostelium discoideum as measured by 14C sucrose or FITC-dextran uptake. Transmission electron microscopic studies also reveal the presence of a greater number of pinosomal vesicles in the pesticide-treated Dictyostelium amoebae. The enhanced pinocytic activity has been discussed in relation to lipophilic interactions of gamma-BHC with the hydrophobic cell surface and the observed changes in the cytoskeletal proteins of the treated cells.

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Section: Resultsmentioning

confidence: 99%