Effect of the Antimicrobial Agents Peppermint Essential Oil and Silver Nanoparticles on Bone Cement Properties

Abstract

The main problems directly linked with the use of PMMA bone cements in orthopedic surgery are the improper mechanical bond between cement and bone and the absence of antimicrobial properties. Recently, more research has been devoted to new bone cement with antimicrobial properties using mainly antibiotics or other innovative materials with antimicrobial properties. In this paper, we developed modified PMMA bone cement with antimicrobial properties proposing some experimental antimicrobial agents consisting of silver nanoparticles incorporated in ceramic glass and hydroxyapatite impregnated with peppermint oil. The impact of the addition of antimicrobial agents on the structure, mechanical properties, and biocompatibility of new PMMA bone cements was quantified. It has been shown that the addition of antimicrobial agents improves the flexural strength of the traditional PMMA bone cement, while the yield strength values show a decrease, most likely because this agent acts as a discontinuity inside the material rather than as a reinforcing agent. In the case of all samples, the addition of antimicrobial agents had no significant influence on the thermal stability. The new PMMA bone cement showed good biocompatibility and the possibility of osteoblast proliferation (MTT test) along with a low level of cytotoxicity (LDH test).

Composite Bone Cements with Enhanced Drug Elution

“…The maximum temperature observed for MFC-containing ALBC in present research is close to the value observed previously [ 48 ]. Nevertheless, it should be underlined that the direct comparison of the polymerization temperatures from different works might be ambiguous since this parameter also strongly depends on the size/shape of the BC sample, the ratio of monomer to polymer, the conditions of the temperature registration (e.g., in vitro or in vivo studies), as well as the degree of heat waste [ 52 , 65 , 66 ].…”

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

“…One study demonstrated that CA-based composite coatings containing hydroxyapatite (HAp) and Mg particles enhanced the corrosion resistance and hydrophilic characteristics of Mg-based implants. [90,91] The most important things to consider in these polymeric coatings are their chemical and biological compatibility with the host tissue and nontoxicity. There are numerous techniques to fabricate high-throughput polymeric coatings, such as Reproduced with permission from.…”

Influence of Lavender Essential Oil on the Physical and Antibacterial Properties of Chitosan Sponge for Hemostatic Applications

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