Effect of the biologically effective dose of electron beam radiation therapy on recurrence rate after keloid excision: A meta-analysis

Hwang, Na-Hyun; Chang, Ji Hyun; Lee, Nam Kwon; Yang, Kyung-Sook

doi:10.1016/j.radonc.2022.06.003

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…However, it has not been effectively controlled, and the recurrence rate remains very high [ 4 ]. Surgical resection and postoperative radiotherapy are still the primary methods for treating keloid lesions, but the recurrence rate after postoperative radiotherapy can also reach 16% [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis

Xiao,

Wang,

Chen

et al. 2024

Hum Genomics

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Background Keloid is a disease characterized by proliferation of fibrous tissue after the healing of skin tissue, which seriously affects the daily life of patients. However, the clinical treatment of keloids still has limitations, that is, it is not effective in controlling keloids, resulting in a high recurrence rate. Thus, it is urgent to identify new signatures to improve the diagnosis and treatment of keloids. Method Bulk RNA seq and scRNA seq data were downloaded from the GEO database. First, we used WGCNA and MEGENA to co-identify keloid/immune-related DEGs. Subsequently, we used three machine learning algorithms (Randomforest, SVM-RFE, and LASSO) to identify hub immune-related genes of keloid (KHIGs) and investigated the heterogeneous expression of KHIGs during fibroblast subpopulation differentiation using scRNA-seq. Finally, we used HE and Masson staining, quantitative reverse transcription-PCR, western blotting, immunohistochemical, and Immunofluorescent assay to investigate the dysregulated expression and the mechanism of retinoic acid in keloids. Results In the present study, we identified PTGFR, RBP5, and LIF as KHIGs and validated their diagnostic performance. Subsequently, we constructed a novel artificial neural network molecular diagnostic model based on the transcriptome pattern of KHIGs, which is expected to break through the current dilemma faced by molecular diagnosis of keloids in the clinic. Meanwhile, the constructed IG score can also effectively predict keloid risk, which provides a new strategy for keloid prevention. Additionally, we observed that KHIGs were also heterogeneously expressed in the constructed differentiation trajectories of fibroblast subtypes, which may affect the differentiation of fibroblast subtypes and thus lead to dysregulation of the immune microenvironment in keloids. Finally, we found that retinoic acid may treat or alleviate keloids by inhibiting RBP5 to differentiate pro-inflammatory fibroblasts (PIF) to mesenchymal fibroblasts (MF), which further reduces collagen secretion. Conclusion In summary, the present study provides novel immune signatures (PTGFR, RBP5, and LIF) for keloid diagnosis and treatment, and identifies retinoic acid as potential anti-keloid drugs. More importantly, we provide a new perspective for understanding the interactions between different fibroblast subtypes in keloids and the remodeling of their immune microenvironment.

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Section: Introductionmentioning

confidence: 99%

Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis

Xiao,

Wang,

Chen

et al. 2024

Hum Genomics

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“…According to the meta-analysis, postoperative adjuvant radiation therapy for earlobe keloids resulted in a lower recurrence rate than keloid lesions at other sites. However, the radiation doses in the studies included were heterogeneous and involved multifraction radiation treatment 5 …”

mentioning

confidence: 99%

“…However, the radiation doses in the studies included were heterogeneous and involved multifraction radiation treatment. 5 This study presents our results of treating earlobe keloids through complete surgical excision followed by immediate postoperative adjuvant single fraction radiation therapy of 10 Gy, either on the same day or the next day.…”

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confidence: 99%

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Efficacy of Immediate Postoperative Single Fractional 10 Gy Radiotherapy for Earlobe Keloids

Han,

Ha,

Chang

et al. 2024

Journal of Craniofacial Surgery

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Background: The ear is a common site for keloid formation, typically due to ear piercing or trauma. Auricular keloids are always difficult to treat and pose a challenging situation. The purpose of this study is to present our experience treating earlobe keloids through complete surgical excision followed by immediate postoperative single fraction 10 Gy radiation therapy either on the same day or the next day. Methods: The authors retrospectively evaluated 48 patients with 71 earlobe keloids treated with complete surgical excision followed by single‐fractional 10 Gy radiotherapy within 24 hours from May 2021 to December 2022. The outcome was reported with a recurrence‐free rate and side effects. Results: The mean follow‐up period was 20.8 months. All patients tolerated the treatments well. The overall recurrence‐free rate was 100%. There were only 2 grade III radiation dermatitis. There were no reports of second malignancies or severe complications. Conclusions: The authors have obtained excellent outcomes from treating earlobe keloids through complete excision followed by postoperative radiotherapy with a single fractional dose of 10 Gy on the same day or the next day.

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Triple Surgical Technique for the Repair of Auricular Keloids: Achieving Perfect Restoration of the Ear Contour

Han,

Jiang,

et al. 2024

Aesth Plast Surg

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Effect of the biologically effective dose of electron beam radiation therapy on recurrence rate after keloid excision: A meta-analysis

Cited by 7 publications

References 45 publications

Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis

Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis

Efficacy of Immediate Postoperative Single Fractional 10 Gy Radiotherapy for Earlobe Keloids

Triple Surgical Technique for the Repair of Auricular Keloids: Achieving Perfect Restoration of the Ear Contour

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