Effect of the components of the metabolic syndrome on pulmonary function. The unexpected role of high-density lipoprotein cholesterol

Huerta-Ramírez, Saúl; Pérez, Angélica Paniagua; Castro-Serna, David; Ledesma-Velázquez, Andrés; Rubio-Guerra, Alberto Francisco; Vargas-Ayala, Germán

doi:10.24875/cirue.m18000025

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…Similarly, the inverse correlation between HDL levels and pulmonary function has been reported recently. 25 In our research, serum HDL levels were also elevated in patients with FEV 1 % less than 30. This change might be partially attributable to the oral steroid use, which was an independent predictor of increased HDL-C in multivariate modeling.…”

supporting

confidence: 60%

<p>The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD</p>

Huang

Jiang

Miao

et al. 2020

COPD

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This study aimed to explore the relation between lymphocyte to high-density lipoprotein ratio (LHR) and pulmonary function of chronic obstructive pulmonary disease (COPD) patients compared with neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Patients and Methods: In total, 154 participants (n = 77 with COPD and n = 77 without COPD) were recruited. LHR, NLR, PLR, lung function and other data were collected and compared. Pearson's correlation test and the receiver operating characteristics curves were used to compare the utility of LHR, NLR and PLR. Besides, univariate and multivariate logistic regression analyses were conducted. Results: COPD patients with poorer lung function had a lower LHR level (P < 0.001). In low LHR group, more patients underwent greater airflow limitation than the other group (P = 0.006). LHR positively correlated with forced expiratory volume in 1 second in percent of the predicted value (FEV 1 %) (r = 0.333, P = 0.003). At a cutoff value of 2.08, the sensitivity and specificity of LHR in predicting FEV 1 % < 50 were 93.2% and 55.6%, respectively, with an AUC of 0.770 (P = 0.001) better than NLR and PLR. Based on logistic regression analyses, it was proved that LHR was associated with decreased risk of FEV 1 <50% predicted in COPD patients (odds ratio = 0.198, 95% CI: 0.048-0.811, P = 0.024). Conclusion: In contrast with NLR and PLR, LHR has higher accuracy for predicting pulmonary function in COPD; lower LHR level is independently associated with poorer pulmonary function.

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supporting

confidence: 60%

<p>The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD</p>

Huang

Jiang

Miao

et al. 2020

COPD

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“…A small case-control study on the relationship between MS and COPD showed that the HDL level of the COPD group was crucially lower than that of the control group (47.1% vs 58%) [29]. Moreover, a small population study [30] found that participants with normal or high levels of HDL-C had lower FVC than those with low levels of HDL-C. e pathophysiological role between the two is still uncertain. It is generally believed that chronic inflammation can accelerate atherosclerosis, which is achieved by changing the HDL level and its capability to advance reverse cholesterol transport [31,32].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Wang

Tian

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. A considerable uncertainty exists about the relationship between adult metabolic syndrome (MS) and obstructive lung disease (OLD), perhaps owing to systemic inflammation. Therefore, this study aimed to investigate the relationship between MS (with its components) and the patterns of lung function impairment. Methods. The participants in this study were 3978 adults aged 30-78 years from the baseline cohort of the Ningxia Cohort Study. The participants underwent pulmonary function tests, questionnaire surveys, physical examinations, and analysis of blood specimens. Results. No significant difference in the prevalence of OLD was observed between male (15.9%) and female (14.2%) participants. After adjusting for possible confounding factors (e.g., age and family income), impaired lung function was found to be related to some MS components, such as abdominal obesity, high blood pressure, and low levels of high-density lipoprotein cholesterol (HDL-C) (all P < 0.05 ). Conclusions. As an important component of MS, abdominal obesity is related to impaired lung function. Surprisingly, this study found that increased HDL-C levels could accelerate the decline of lung function; it also suggests that in the presence of different metabolic health conditions, especially abdominal obesity and low levels of HDL-C, various metabolic indicators should be comprehensively considered to prevent the decline of lung function. This partly explains the increase in the incidence of two or more chronic diseases. Therefore, the prevention of chronic diseases should shift from single-disease prevention to a comprehensive consideration of multi-disease prevention in the future. Therefore, a more sensitive evaluation of the role of HDL-C in lung function is warranted.

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“…A small case-control study reported that HDL levels in the COPD group were signi cantly lower than those in the control group (47.1% vs 58%) [28]. A small population study in Mexico [29] observed that subjects with normal or elevated high-density lipoprotein cholesterol had lower FVC than subjects with low-density lipoprotein cholesterol. The pathophysiological role of this link is unknown.…”

Section: Discussionmentioning

confidence: 95%

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

Wang¹,

Tian²,

Zhao³

et al. 2020

Preprint

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Background There remains considerable uncertainty about the association between adult metabolic syndrome (MetS) and obstructive lung disease (OLD) possibly through generalized systemic inflammation. The purpose of this study was to investigate the relationship between MetS and its components and lung function patterns. Methods Participants (n = 3978) were drawn from Pingluo and Qingtongxia residents at baseline from the Ningxia Cohort Study. The MetS was assessed according to the criteria of National Cholesterol Education Program III. Spirometric parameters were measured to define lung function. Through multiple linear regression and logistic regression analysis, these relationships were tested. Results The prevalence of obstructive lung disease (OLD) was comparable between genders (15.9% and 14.2%). The prevalence of obstructive pulmonary disease (OLD) was comparable between genders (15.9% and 14.2%), but the prevalence of MetS in males with co-existent OLD was lower than that in females (32.9% and 40.8%). After adjusting for potential confounders such as age and family income group, impaired lung function was associated with individual components of the metabolic syndrome, such as abdominal obesity, hypertension, and low HDL -C(all parameters were p < 0.05). Conclusions As an important component of MetS, abdominal obesity is associated with impaired lung function. Surprisingly, there is a negative correlation between HDL-C and lung function, and the presence of this relationship suggests a new understanding of the role of HDL-C.

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Effect of the components of the metabolic syndrome on pulmonary function. The unexpected role of high-density lipoprotein cholesterol

Abstract: Effect of the components of the metabolic syndrome on pulmonary function. The unexpected role of high-density lipoprotein cholesterolEfecto de los componentes del síndrome metabólico en la función pulmonar. El inesperado papel del colesterol ligado a lipoproteínas de alta densidad

Cited by 7 publications

References 15 publications

<p>The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD</p>

<p>The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD</p>

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

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