Effect of the composition of hydroxyapatite/bioactive glass nanocomposite foams on their bioactivity and mechanical properties

Ghomi, Hamed; Fathi, Mohammad Hossein; Edris, Hossein

doi:10.1016/j.materresbull.2012.06.066

Cited by 61 publications

(32 citation statements)

References 38 publications

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“…The elastic modulus was calculated according to the slope of the initial linear portion of the stress-strain graphs. The final results were presented based on the average results of the 3 samples of each type of composite [11].…”

Section: Mechanical Testingmentioning

confidence: 99%

“…However, its biological and physico-chemical properties can be reinforced by substituting ions that are normally present in natural bone apatite [10]. The intrinsic fragility of glass is the main limitation of using bioactive glass as tissue-engineering scaffolds [11].…”

Section: Introductionmentioning

confidence: 99%

“…According to different studies, the optimal size for osteoconductivity is 150-600 µm [25]. The mechanical properties of scaffold should provide sufficient mechanical stability before the regeneration of new tissue in areas under load [11].…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, there are various technologies for manufacturing high porosity bioceramics [11]. The gelcasting method is an appropriate method for manufacturing ceramic materials with high rigidity and dimensional accuracy, homogeneous structure and various complex forms [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

“…In this process, foaming is done by adding foaming agents and vigorous agitation of aqueous ceramic suspension. Natural proteins and polysaccharides such as agarose are often used in new gelcasting systems [11,29,30].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Seyedmajidi¹,

Seyedmajidi²,

Alaghehmand³

et al. 2018

Eurasian J Anal Chem

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The aim of this study was to synthesize and characterization of hydroxyapatite/bioactive glass (HA/BG) nanocomposite foam and fluorapatite/bioactive glass (FA/BG) nanocomposite foam by gel casting method as cell scaffold for bone tissue engineering and evaluating their bioactivity using in vitro methods. Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Archimedes method and universal testing machine were used in order to evaluate specific surface area, phase composition, shape, size and interconnectivity of pores, size and shape of the constructed foam particles, porosity measurement and compressive strength of prepared nanocomposite foams, respectively. Mean particle size of HA/BG and FA/BG nanocomposite foams were 78 and 42 nm respectively with average pore size ranges was from 100 to 400 µm for two compositions. The maximum values of compressive strength and elastic modulus of nanocomposite foams were 0.22 and 17.8 Mpa for HA/BG and 0.13 and 22 MPa for FA/BG, respectively. The mean values of the apparent and true porosity were calculated 31 and 78% for HA/BG and 42 and 77% for FA/BG, respectively. The results of in vitro immersion of foams in simulated body fluid (SBF) demonstrate the formation of apatite on the surface of foams that indicating their bioactivity. The prepared nanocomposite foams in this research are appropriate substitutes for the bone defects in tissue engineering due to their characteristics. Moreover, using gel casting method to introduce these bioceramics provides the possibility to construct foams by molding or 3D printing in a desired shapes in accordance to patient's needs with high dimensional accuracy.

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Section: Mechanical Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Seyedmajidi¹,

Seyedmajidi²,

Alaghehmand³

et al. 2018

Eurasian J Anal Chem

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A comparative study on cytotoxicity and genotoxicity of the hydroxyapatite‐bioactive glass and fluorapatite‐bioactive glass nanocomposite foams as tissue scaffold for bone repair

Seyedmajidi

Zabihi

et al. 2018

J Biomedical Materials Res

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Considering to the possibility of cellular and genetic damage by the implant materials in the patient and the clinician, the safety of the biomaterials should be evaluated. The purpose of this study was to compare the cytotoxicity and genotoxicity induced by two nanocomposites, hydroxyapatite/bioactive glass (HA/BG) and fluorapatite/bioactive glass (FA/BG) in vitro. Biomaterial extracts (BMEX, 100%) were prepared by incubating 100 mg/mL of each biomaterial powder in complete culture medium (RPMI1640 + 10% FBS) for 72 h. Saos-II cells were exposed to different concentrations of BMEXs for different periods of time and evaluated at the end of each period. According to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay results, both BMEXs at low concentrations (<25%) has no inhibitory effects on the cells growth. After 24 h of exposure, only HA/BG BMEX at 100% concentration showed significant cytotoxic effect. After 48 and 72 h, both HA/BG and FA/BG BMEXs showed similar cytotoxic effect at concentration higher than 75 and 50%, respectively. The results of the comet assay showed that the tail elongation, and proportionally DNA damage, increased in a dose/time dependently fashion with BMEXs exposure. Based on low and similar cytotoxicity and genotoxicity profiles on the Saos-II cell line, it could be concluded that FA/BG, like HA/BG, could be a good candidate for further in vivo biocompatibility studies to be used in bone tissue repair. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2605-2612, 2018.

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Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Abulyazied

Alturki

Youness

et al. 2021

J Inorg Organomet Polym

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In this work, a borosilicate glass sample (5SiO -45B 2 O 3 -20Na 2 O-25CaO-5Ag 2 O) was added to nano-sized carbonated hydroxyapatite (CHA) powders with different contents up to 20 wt.% to improve the bioactivity, antibacterial effect, physical and mechanical properties of the resulting nanocomposites. Then, these samples were mixed, milled with a high-energy ball mill, sintered at 700°C and subjected to Xray diffraction (XRD) technique, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to examine their structure, chemical composition and microstructure, respectively. Furthermore, the physical and mechanical properties of the sintered nanocomposites were also measured. Moreover, the in vitro bioactivity of the prepared nanocomposites was examined with XRD and SEM. Additionally, the antibacterial behavior of these samples was tested against E. coli and S. aureus by the disc-diffusion method. The results obtained pointed out that the sample with the highest content of BG possessed the best bioactivity, antibacterial effect, physical and mechanical properties.

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Effect of the composition of hydroxyapatite/bioactive glass nanocomposite foams on their bioactivity and mechanical properties

Cited by 61 publications

References 38 publications

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

A comparative study on cytotoxicity and genotoxicity of the hydroxyapatite‐bioactive glass and fluorapatite‐bioactive glass nanocomposite foams as tissue scaffold for bone repair

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

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