Effect of the Consumption of a Cheese Enriched With Probiotic Organisms (Bifidobacterium Lactis Bi-07) in Improving Symptoms of Constipation

Favretto, Diane Cassia; Pontin, Bruna; Moreira, Thaís Rodrigues

doi:10.1590/s0004-28032013000200035

Cited by 41 publications

(21 citation statements)

References 19 publications

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“…Thus, CCFM 667 and 669 could relieve constipation, whereas CCFM 626 could not. Published data hold that supplementation of Bifidobacterium is associated with a slower whole intestinal transit time in the human gut [34], a finding that was confirmed by Favretto [35]. …”

Section: Discussionmentioning

confidence: 84%

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Wang

et al. 2017

IJMS

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Constipation is one of the most common gastrointestinal complaints worldwide. This study was performed to determine whether Bifidobacterium adolescentis exerts inter-strain differences in alleviating constipation induced by loperamide in BALB/c mice and to analyze the main reasons for these differences. BALB/c mice underwent gavage with B. adolescentis (CCFM 626, 667, and 669) once per day for 17 days. The primary outcome measures included related constipation indicators, and the secondary outcome measures were the basic biological characteristics of the strains, the concentration changes of short-chain fatty acids in feces, and the changes in the fecal flora. B. adolescentis CCFM 669 and 667 relieved constipation symptoms by adhering to intestinal epithelial cells, growing quickly in vitro and increasing the concentrations of propionic and butyric acids. The effect of B. adolescentis on the gut microbiota in mice with constipation was investigated via 16S rRNA metagenomic analysis. The results revealed that the relative abundance of Lactobacillus increased and the amount of Clostridium decreased in the B. adolescentis CCFM 669 and 667 treatment groups. In conclusion, B. adolescentis exhibits strain-specific effects in the alleviation of constipation, mostly due to the strains’ growth rates, adhesive capacity and effects on the gut microbiome and microenvironment.

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Section: Discussionmentioning

confidence: 84%

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Wang

et al. 2017

IJMS

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“…Previous evidence supports that Bifidobacterium animalis subsp. lactis Bi-07 at 10 9 CFU per day met criteria for a probiotic 112 , 129 . Taken together, this tested product meets our definition of a complementary synbiotic.…”

mentioning

confidence: 99%

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Swanson

Gibson

Hutkins

et al. 2020

Nat Rev Gastroenterol Hepatol

1,109

455

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In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

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“…A significant improvement of symptoms of constipation was observed, but no significant difference between the groups (20) . Different results were found in a study in which Brazilian women participants in the intervention group consumed cheese enriched with probiotic Bifidobacteruim lactis for 30 days (7) . A positive effect was observed in five of the six ROME III criteria in the intervention group, while the control group showed improvement in three of these criteria.…”

Section: Discussionmentioning

confidence: 66%

Influence of Drinking a Probiotic Fermented Milk Beverage Containing Bifidobacterium Animalis on the Symptoms of Constipation

Moreira

Leonhardt

Conde

2017

Arq. Gastroenterol.

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-Background -Constipation is a chronic problem in many patients all over the world. Objective -To evaluate the effect of consumption of a probiotic fermented milk beverage containing Bifidobacterium animalis on the symptoms of constipation. Methods -This randomized, double-blind controlled trial included 49 female patients aged 20 to 50 years and diagnosed with constipation according to the ROME III criteria (Diagnostic Criteria for Functional Gastrointestinal Disorders) and the Bristol Stool Form Scale. The patients were randomized into two groups: the intervention group received the probiotic fermented milk beverage and the control group received non-probiotic milk. Participants were instructed to ingest 150 mL of the beverages during 60 days. At the end of this period, patients were assessed again by the ROME III criteria and Bristol scale. The Wilcoxon test was used to evaluate pre and post-intervention results of the ROME III criteria and Bristol scale. The statistical significance level was considered as 5% (P≤0.05). Results -The intervention group showed improvement in the following criteria: straining during a bowel movement (P<0.001), feeling of incomplete evacuation (P<0.001) and difficulty in passing stool (P<0.014), in addition to Bristol scale results (P<0.001). In the control group, improvements were observed in the following criteria: straining during a bowel movement (P<0.001), feeling of incomplete evacuation (P<0.001) and difficulty in passing stool (P<0.025), in addition to Bristol scale results (P<0.001). No statistically significant post-intervention differences were observed between the two groups for the Rome III criteria and Bristol scale. Conclusion -The results show that the consumption of milk resulted in the improvement of constipation symptoms, regardless of the probiotic culture.

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Effect of the Consumption of a Cheese Enriched With Probiotic Organisms (Bifidobacterium Lactis Bi-07) in Improving Symptoms of Constipation

Cited by 41 publications

References 19 publications

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Influence of Drinking a Probiotic Fermented Milk Beverage Containing Bifidobacterium Animalis on the Symptoms of Constipation

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