Effect of the COVID-19 Pandemic on Kidney Transplant and on Chronic Dialysis Patients

Amsei, Thamiris Quiqueto Marinelli; Gorayeb-Polacchini, Fernanda Salomão; Caldas, Heloisa Cristina; Fernandes-Charpiot, Ida Maria Maximina; Ferreira-Baptista, M.A.S.; Abbud-Filho, Mário

doi:10.1016/j.transproceed.2022.02.061

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The incidence of COVID-19 in patients undergoing RRT was considerably lower than that in the general population. Many other studies [15] have reported a higher incidence of COVID-19 in patients on RRT than in the general population; however, some of these studies explained that because patients on RRT frequently visit medical centers and are perceived to be a high-risk group, COVID-19 tests are more readily available to them than to the general population [16,17]. In South Korea, the costs of COVID-19 testing and treatment after diagnosis were covered by the government, and indications for COVID-19 testing were strictly regulated.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea

Choi,

Kim,

Park

et al. 2024

Kidney Res Clin Pract

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Background:The global coronavirus disease 2019 (COVID-19) pandemic has placed patients with end-stage kidney disease (ESKD) at heightened risk owing to their vulnerability to infections. Our study focused on patients with ESKD, examining COVID-19 incidence, hospitalization, and mortality in relation to their renal replacement therapy (RRT) type and identifying factors influencing COVID-19 hospitalization. Methods: We conducted a retrospective cohort study using health insurance claims data from the Health Insurance Review and Assessment Service for patients with ESKD between July 2017 and June 2022. COVID-19 data for the general population were sourced from the Korea Disease Control and Prevention Agency. Results: Patients undergoing hemodialysis (HD) constituted 90.7% of the cohort, followed by kidney transplantation (KT) recipients and peritoneal dialysis (PD). After adjusting for every 10,000 individuals, KT recipients exhibited the highest COVID-19 incidence, followed by those undergoing HD and PD, whereas the general population showed a higher infection rate of 43.64. Patients undergoing HD had the highest hospitalization rates, followed by KT recipients and those undergoing PD. The mortality rate per 10,000 individuals was highest in HD, followed by PD, the general population, and KT. Multivariate analysis indicated that age, RRT duration, residence in a nursing hospital, and comorbidities were associated with COVID-19 hospitalization. Conclusion: Among RRT modalities, KT recipients displayed the highest COVID-19 incidence, whereas those undergoing HD exhibited the highest hospitalization and mortality rates. This study contributes to our understanding of infectious diseases in patients on RRT and aids in preparedness for future infectious disease outbreaks.

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Section: Discussionmentioning

confidence: 99%

COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea

Choi,

Kim,

Park

et al. 2024

Kidney Res Clin Pract

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“…However, evidence on the impact of immunosuppression on COVID-19 prognosis, as well as the disparities in outcomes among KT recipients and chronic dialysis patients remains a subject of contention in current research (6)(7)(8). Furthermore, during the COVID-19 pandemic, there was a reduction in morbidity and mortality rates related to improvements in the management, the emergence of variants, and especially vaccination of patients (9).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcomes in COVID-19 in kidney transplant recipients: a propensity score matched cohort study

Delfino-Pereira,

Ventura,

Pires

et al. 2024

Front. Med.

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Patients with chronic kidney disease (CKD), especially those on dialysis or who have received a kidney transplant (KT), are considered more vulnerable to severe COVID-19. This susceptibility is attributed to advanced age, a higher frequency of comorbidities, and the chronic immunosuppressed state, which may exacerbate their susceptibility to severe outcomes. Therefore, our study aimed to compare the clinical characteristics and outcomes of COVID-19 in KT patients with those on chronic dialysis and non-CKD patients in a propensity score-matched cohort study. This multicentric retrospective cohort included adult COVID-19 laboratory-confirmed patients admitted from March/2020 to July/2022, from 43 Brazilian hospitals. The primary outcome was in-hospital mortality. Propensity score analysis matched KT recipients with controls - patients on chronic dialysis and those without CKD (within 0.25 standard deviations of the logit of the propensity score) - according to age, sex, number of comorbidities, and admission year. This study included 555 patients: 163 KT, 146 on chronic dialysis, and 249 non-CKD patients (median age 57 years, 55.2% women). With regards to clinical outcomes, chronic dialysis patients had a higher prevalence of acute heart failure, compared to KT recipients, furthermore, both groups presented high in-hospital mortality, 34.0 and 28.1%, for KT and chronic dialysis patients, respectively. When comparing KT and non-CKD patients, the first group had a higher incidence of in-hospital dialysis (26.4% vs. 8.8%, p < 0.001), septic shock (24.1% vs. 12.0%, p = 0.002), and mortality (32.5% vs. 23.3%, p = 0.039), in addition to longer time spent in the intensive care unit (ICU). In this study, chronic dialysis patients presented a higher prevalence of acute heart failure, compared to KT recipients, whereas KT patients had a higher frequency of complications than those without CKD, including septic shock, dialysis during hospitalization, and in-hospital mortality as well as longer time spent in the ICU.

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Analysis of COVID-19 Infection in Kidney Transplant Recipients

Marinelli,

Caldas,

Ferreira-Baptista

et al. 2024

Transplantation Proceedings

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Effect of the COVID-19 Pandemic on Kidney Transplant and on Chronic Dialysis Patients

Cited by 3 publications

References 10 publications

COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea

COVID-19 infection in patients with end-stage kidney disease undergoing renal replacement therapies in Korea

Clinical characteristics and outcomes in COVID-19 in kidney transplant recipients: a propensity score matched cohort study

Analysis of COVID-19 Infection in Kidney Transplant Recipients

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