While well-being is known to be mainly predicted by relatively stable personality traits and demographic factors, under circumstances of the current COVID-19 pandemic, the role of these predictors may be attenuated, and more situational factors may come into play. In the present study, we examined those relatively stable predictors of well-being along with COVID-19 specific factors, such as the perception of health and economic threat, unrealistic optimism, lack of control, trust in government regulations, and the endorsement of conspiracy beliefs. The data collection took place in early November 2020, when the second wave in Slovakia started to gain momentum and the strict lockdown was issued. Slovak adults (
N =
1020) reported their current positive and negative affect and current, as well as estimated pre-pandemic and predicted future life satisfaction. The results showed that positive and negative affect was predicted mainly by extraversion and negative emotionality. On the other hand, life satisfaction, and its perceived change from before the pandemic and in three months, was predicted mainly by COVID-19 factors, especially perceived economical threat, unrealistic optimism, and trust in governmental regulations. We discuss the importance of these factors when considering the effect of the COVID-19 pandemic on peoples' well-being.