Effect of the electrochemical characteristics of titanium on the adsorption kinetics of albumin

Liamas, Evangelos; Thomas, Owen R.T.; Muñoz, A. Igual; Zhang, Zhenyu J.

doi:10.1039/c9ra05988a

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…Adsorption of proteins in biological fluids is one of the initial steps that affects the biocompatibility of the implants inside a human body [66]. BSA adsorption was observed and corroborated either by in-situ electrochemical and/or ex-situ surface analysis techniques by different authors [24,26,29,30,34,39,[42][43][44]46,50,[67][68][69][70]. Indeed, several reviews dedicated to adsorption phenomena involving various proteins exist in the literature [3,9,15,71].…”

Section: Albumin Adsorptionmentioning

confidence: 91%

“…Thus, the shift of the resonance frequency provides a quantitative estimation of the mass change of the working electrode. It has been successfully used to study the adsorption and precipitation phenomena of BSA on different biomedical alloys [34,[39][40][41]55,57]. The reversibility of protein adsorption also is determined using the EQCM technique with a flow-cell system which allows us to change, in a controlled way, the chemistry of the solution (i.e., injecting proteins through a fluidic system) [61].…”

Section: Experimental Techniques Used To Study Interactions Of Albumi...mentioning

confidence: 99%

“…Electrochemical techniques are the experimental techniques used to study in-situ the interaction of proteins with biomedical alloys [58]. Particularly, potentiostatic and potentiodynamic tests are extensively used and useful for understanding and quantifying protein adsorption, precipitation, and reduction [24,[29][30][31]34,39,55,56] as these phenomena are influenced by the prevailing potential at the interface.…”

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confidence: 99%

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An Overview of Serum Albumin Interactions with Biomedical Alloys

2020

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Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompatibility of biomedical alloys. The interaction of albumin with biomedical alloys is a complex process influenced by numerous factors. This literature overview aims at presenting the current understanding of the mechanisms of serum albumin (both Bovine Serum Albumin, BSA, and Human Serum Albumin, HSA) interactions with biomedical alloys, considering only those research works that present a mechanistic description of the involved phenomena. Widely used biomedical alloys, such as 316L steel, CoCrMo and Titanium alloys are specifically addressed in this overview. Considering the literature analysis, four albumin-related phenomena can be distinguished: adsorption, reduction, precipitation, and protein-metal binding. The experimental techniques used to understand and quantify those phenomena are described together with the studied parameters influencing them. The crucial effect of the electrochemical potential on those phenomena is highlighted. The effect of the albumin-related phenomena on corrosion behavior of biomedical materials also is discussed.

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Section: Albumin Adsorptionmentioning

confidence: 91%

Section: Experimental Techniques Used To Study Interactions Of Albumi...mentioning

confidence: 99%

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confidence: 99%

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An Overview of Serum Albumin Interactions with Biomedical Alloys

2020

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“…The pH of the solution was 2.6 at the beginning. It was then placed in a thermostatic water bath at 65 °C overnight under static settings until the reaction mixture was bright pink [30][31][32].…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Fabrication of protein-coated titanium dioxide nanoparticles for cellular uptake fluorescence imaging and treatment of colorectal cancer

Zhang¹,

Wang²,

Yu³

2021

Mater. Res. Express

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We effectively fabricated Titanium dioxide nanoparticles that were protein-coated. Bovine serum albumin (BSA), lysozyme proteins, zein, and collagen have been used to coat titanium dioxide-aryl nanoparticles of the form TiO2-NPs. However, in both cases, no catalysts or other stabilising agents were used. These images of TiO2-NPs fabricated using the green method show high crystallinity. It is a malignant colorectal tumour with dysfunctional cellular processes that cause colorectal cancer cells. It is hoped that studies employing SW1417 cells would give mechanistic ideas on the specifics of the amplification in cancers. This was done by flow cytometry utilising and laser confocal fluorescence microscopy (LCFM) on the SW1417 colorectal cell line. Of the protein-coated Titanium dioxide nanoparticles fabricated green methods, BSA@TiO2-NPs were the most readily absorbed. Of all TiO2-NPs, lysozyme@TiO2-NPs fabricated by the chemical reduction technique were the most effectively internalised by SW1417 cells out of TiO2-NPs types.

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“…Previous research has shown that these constituents have a various influence on the corrosion behavior of Ti. For example, BSA can inhibit the reduction reaction by adsorbing onto the metal surfaces [ 8 , 9 , 10 , 11 , 12 , 13 ]. However, depending on the concentration, protein either can accelerate the corrosion rate of metallic implants by forming soluble complexes with metal ions [ 11 , 12 , 14 ] or inhibit corrosion by acting as a physical barrier layer [ 11 , 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Electrochemical Behavior of Ti in Human Synovial Fluids

et al. 2022

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In this study, we report results of the interaction of titanium (Ti) with human synovial fluids. A wide palette of electrochemical techniques was used, including open circuit potential, potentiodynamic methods, and electrochemical impedance. After the electrochemical testing, selected surfaces were analyzed using Auger Electron Spectroscopy to provide laterally resolved information on surface chemistry. For comparison purposes, similar tests were conducted in a series of simulated body fluids. This study shows that compared to the tested simulated body fluids, synovial liquids show a large patient variability up to one order of magnitude for some crucial electrochemical parameters such as corrosion current density. The electrochemical behavior of Ti exposed to human synovial fluids seems to be controlled by the interaction with organic molecules rather than with reactive oxygen species.

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Effect of the electrochemical characteristics of titanium on the adsorption kinetics of albumin

Abstract: An EQCM was used to examine the electrochemical behaviour of pure titanium in PBS and PBS-containing BSA solutions, and the associated adsorption characteristics of BSA under cathodic and anodic applied potentials.

Cited by 10 publications

References 49 publications

An Overview of Serum Albumin Interactions with Biomedical Alloys

An Overview of Serum Albumin Interactions with Biomedical Alloys

Fabrication of protein-coated titanium dioxide nanoparticles for cellular uptake fluorescence imaging and treatment of colorectal cancer

The Electrochemical Behavior of Ti in Human Synovial Fluids

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