Effect of the eluent on enantiomer separation of controlled drugs by liquid chromatography–ultraviolet absorbance detection–electrospray ionisation tandem mass spectrometry using vancomycin and native β-cyclodextrin chiral stationary phases

Pihlainen, Katja; Kostiainen, Risto

doi:10.1016/j.chroma.2003.12.073

Cited by 35 publications

(15 citation statements)

References 32 publications

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“…10,29 Fentanyls fragmented in MS/MS experiments mainly through neutral loss of the amide moiety (route A) and neutral loss of the amine moiety (route B). The third important fragmentation route was the cleavage of the piperidine ring and loss of the propionyl group (route C) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) and matrix-assisted laser desorption ionization mass spectrometry (AP-MALDI-MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP-DIOS-MS/MS and AP-MALDI-MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP-DIOS-MS/MS were 1-3 pmol, indicating excellent sensitivity of the method. The LODs with AP-MALDI-MS/MS were about 5-10 times higher.

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Section: Resultsmentioning

confidence: 99%

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Pihlainen

Grigoras²,

Franssila³

et al. 2005

J. Mass Spectrom.

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“…The enantioseparation of nine amphetamine derivatives was studied by comparing two different chiral stationary phases, macrocyclic antibiotic vancomycin and native ␤-cyclodextrin (␤-CD) [27]. Effects of 46 eluent compositions on enantioseparation in reversed-phase and polar organic phase modes were investigated.…”

Section: Amphetaminesmentioning

confidence: 99%

Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography–electrospray ionisation mass spectrometry

2005

Journal of Chromatography B

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“…There have been reports on a variety of analytical methodologies for separating enantiomers of illicit drugs and controlled substances, including gas chromatography (GC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE), GC‐MS, LC‐MS, and CE‐ESI‐MS . One approach may be superior to another depending on the goal of the investigator and the nature of the problems to be solved.…”

Section: Introductionmentioning

confidence: 99%

“…There have been reports on a variety of analytical methodologies for separating enantiomers of illicit drugs and controlled substances, including gas chromatography (GC), [1,[19][20][21] high performance liquid chromatography (HPLC), [1,[22][23][24][25][26][27][28] capillary electrophoresis (CE), [14,29] GC-MS, [30][31][32] LC-MS, [33][34][35][36] and CE-ESI-MS. [37] One approach may be superior to another depending on the goal of the investigator and the nature of the problems to be solved. Clearly, one method may be useful for biological assays while another approach is better suited for forensic assays or quality control of pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric separations of illicit drugs and controlled substances using cyclofructan‐based (LARIHC) and cyclobond I 2000 RSP HPLC chiral stationary phases

Padivitage

Dodbiba

Breitbach

et al. 2013

Drug Testing and Analysis

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Recently a novel class of chiral stationary phases (CSPs) based on cyclofructan (CF) has been developed. Cyclofructans are cyclic oligosaccharides that possess a crown ether core and pendent fructofuranose moieties. Herein, we evaluate the applicability of these novel CSPs for the enantiomeric separation of chiral illicit drugs and controlled substances directly without any derivatization. A set of 20 racemic compounds were used to evaluate these columns including 8 primary amines, 5 secondary amines, and 7 tertiary amines. Of the new cyclofructan based LARIHC columns, 14 enantiomeric separations were obtained including seven baseline and seven partial separations. The LARIHC CF6-P column proved to be the most useful in separating illicit drugs and controlled substances accounting for 11 of the 14 optimized separations. The polar organic mode containing small amounts of methanol in acetonitrile was the most useful solvent system for the LARIHC CF6-P CSP. Furthermore, the LARIHC CF7-DMP CSP proved to be valuable for the separation of the tested chiral drugs resulting in four of the optimized enantiomeric separations, whereas the CF6-RN did not yield any optimum separations. The broad selectivity of the LARIHC CF7-DMP CSP is evident as it separated primary, secondary and tertiary amine containing chiral drugs. The compounds that were partially or un-separated using the cyclofructan based columns were screened with a Cyclobond I 2000 RSP column. This CSP provided three baseline and six partial separations.

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Effect of the eluent on enantiomer separation of controlled drugs by liquid chromatography–ultraviolet absorbance detection–electrospray ionisation tandem mass spectrometry using vancomycin and native β-cyclodextrin chiral stationary phases

Cited by 35 publications

References 32 publications

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures

Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography–electrospray ionisation mass spectrometry

Enantiomeric separations of illicit drugs and controlled substances using cyclofructan‐based (LARIHC) and cyclobond I 2000 RSP HPLC chiral stationary phases

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