Effect of the Hydrocortisone on the Formation of Collagen in Guinea Pig Skin

Effect of ascorbic acid on urinary hydroxyproline of children receiving corticosteroids

“…Administration of corticoids results in a decreased formation of collagen (Siuko et al, 1959;Kivirikko, 1963), with a decreased urinary hydroxyproline excretion (Kibrick et al, 1968;Liakakos et al, 1971) associated with inhibition of growth in children (Van Metre and Pinkerton, 1959;Falliers et al, 1963;Blodgett et al, 1965).…”

“…Although the exact mechanism of the bone action of corticoids is unclear, it is known that corticoid administration is followed by a decrease in the formation of collagen (Siuko, Savela, and Kulonen, 1959;Kivirikko, 1963), and this is shown by a decrease in the urinary hydroxyproline excretion in children (Kibrick et al, 1968;Liakakos et al, 1971). The significance of ascorbic acid in the formation of collagen has been known for a long time (Wolbach and Howe, 1926;Hunt, 1941;Gould and Woessner, 1957) and more recently it has been shown that ascorbic acid can neutralize the inhibitory action of different substances, e.g.…”

Effect of Ascorbic Acid (Vitamin C) on the Epiphyseal Plate of Young Guinea Pigs Receiving Prednisolone

“…Most authors agree, however, in that corticosteroids inhibit bone collagen production (11,26) by preventing the hydroxylation of procollagen proline to peptide-bound hydroxyproline (HOP) (4,27). This results in a decrease of urinary HOP in children (16) and young experimental animals (12).…”