Effect of the Immunosuppressive Agent, Ciclosporin, on Experimental Immune Complex Glomerulonephritis in Rats

Fujita, Masuo; Iida, Hiroyuki; Asaka, Mitsuhiro; Izumino, Kiyoshi; Takata, Masanobu; Sasayama, Shígetake

doi:10.1159/000186251

Cited by 15 publications

(2 citation statements)

References 8 publications

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“…In an experimental study, we have reported that CsA suppressed the immune mechanisms responsible for the antibody production seen in immune complex glomerulonephritis in the rat. 13 The early responsiveness of membranous nephropathy to CsA may be related to its hemodynamic effect. 14 It has also been suggested that CsA may improve the barrier dysfunction of GBM that is caused by cell-mediated immunity in membranous nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Effect of cyclosporine therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome

Iida

Naito

Sakai

et al. 2000

Clinical and Experimental Nephrology

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Background. Recent studies suggested the possible benefits of cyclosporine (CsA) therapy in patients with membranous nephropathy, although most of these studies were shortterm. An uncontrolled retrospective study was undertaken to evaluate the long-term effect of CsA therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome. Methods. The subjects were eight patients with idiopathic membranous nephropathy presenting with refractory nephrotic syndrome. All patients had received a course of corticosteroid therapy before CsA therapy, and had not responded to the corticosteroid, including one or two administrations of intravenous methylprednisolone pulse therapy. The CsA doses were adjusted to maintain trough blood level at 100 ng/ml during the first 3 months and then reduced to maintain the level at 50 ng/ml in patients who had responded to partial remission. Results. CsA therapy induced a marked decrease in proteinuria from the first month, and a significant decrease from month 3 and thereafter. The mean serum total protein and albumin levels rose, and total cholesterol fell significantly with CsA therapy. The serum creatinine level was unchanged during CsA therapy. Three patients showed complete remission and two were in partial remission, while three were nephrotic at 12 months of CsA therapy. From 18 to 24 months of CsA therapy, three patients were in complete remission, four were in partial remission, and one patient was nephrotic. There were no side effects of CsA, except for gum hyperplasia and hypertrichosis in one patient. Conclusion. These results suggest that long-term CsA therapy at a low or moderate dose is potentially effective and safe in most nephrotic patients with idiopathic membranous nephropathy refractory to corticosteroid therapy.

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Section: Discussionmentioning

confidence: 99%

Effect of cyclosporine therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome

Iida

Naito

Sakai

et al. 2000

Clinical and Experimental Nephrology

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“…The aim of this study was to explore the efficacy of SPE more comprehensively in a rat model of immune complex glomerulonephritis (ICG) induced by bovine serum albumin (BSA) and complete Freund’s adjuvant (CFA) in an attempt to explain the underlying mechanism, knowing that this animal model is closely relevant to human mesangial proliferative glomerulonephritis (MsPGN) (Fujita et al. 1991 ; Jia and Zou 1996 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis

Yang

Wang

Gao

et al. 2017

Pharmaceutical Biology

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Context:Salvia przewalskii Maxim. (Lamiaceae) is a Chinese herbal medicine that has long been used for the treatment of cardiovascular disease.Objective: The study investigated the therapeutic efficacy of S. przewalskii total phenolic acid extract (SPE) on immune complex glomerulonephritis (ICG) in rats.Materials and methods: Sixty-two Wistar rats were randomized into six groups. ICG was induced in all groups except normal control group. SPE was administered intragastrically at 24 h intervals for 40 consecutive days. Urine protein (UP), total serum protein (TSP), serum albumin (SA), serum cholesterol (SC) and serum urea nitrogen (SUN) were measured one day before, on day 20 and 40 after SPE administration. On day 40 after SPE administration, the kidneys were removed and prepared into pathologic sections. In addition, kidney wet mass was measured for calculating the kidney wet mass coefficient (KWMC).Results: UP excretion was reduced significantly on day 20 after SPE administration in all three SPE groups as compared with that in medium group, and this effect was observable continuously until 40 days after SPE administration. Compared with medium group, TSP and SA were increased in all three SPE groups after 40 days treatment, while SC and SUN were decreased. KWMC was decreased significantly in 100 mg/kg SPE group after 40 days treatment compared with that in medium group. Histopathologic analyses showed that renal inflammatory infiltration and kidney intumesce were alleviated in all three SPE groups.Conclusions: SPE may be a potential therapeutic drug for glomerulonephritis.

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Antiarthrotic and immunmodulatory activity

Vogel¹,

Vogel²,

Schölkens³

et al. 2002

Drug Discovery and Evaluation

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Effect of the Immunosuppressive Agent, Ciclosporin, on Experimental Immune Complex Glomerulonephritis in Rats

Cited by 15 publications

References 8 publications

Effect of cyclosporine therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome

Effect of cyclosporine therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome

The effects of Salvia przewalskii total phenolic acid extract on immune complex glomerulonephritis

Antiarthrotic and immunmodulatory activity

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