Effect of the interaction between periodontitis and type 1 diabetes mellitus on alveolar bone, mandibular condyle and tibia

Kim, Ji Hye; Lee, Dong‐Eun; Gunawardhana, Kuda Singappulige Niluka Darshani; Choi, Seong‐Ho; Woo, Gye Hyeong; Heon, Jeong; Bak, Eun‐Jung; Yoo, Yun‐Jung

doi:10.3109/00016357.2013.822551

Cited by 25 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 When bone loss was measured, the number of sites with bone loss > 15% in poorly controlled type 1 diabetes mellitus was also 2-fold higher.Animal studies have shown that periodontal bone loss in type 1 diabetes mellitus rats increased ~3-fold compared with normal rats. 15,16 Studies of the Pima Indians provide strong evidence of the link between type 2 diabetes mellitus and periodontal disease. These studies found that the age-and sex-adjusted prevalence of periodontal disease was 60% in type 2 diabetes mellitus subjects compared with 36% in those without periodontal disease.…”

mentioning

confidence: 99%

The impact of diabetes on periodontal diseases

Graves

Ding

Yang

2019

Periodontology 2000

237

172

View full text Add to dashboard Cite

The susceptibility and severity of periodontal diseases is made more severe by diabetes, with the impact on the disease process inversely proportional to the level of glycemic control. Although type 1 diabetes mellitus and type 2 diabetes mellitus have different etiologies, and their impact on bone is not identical, they share many of the same complications. Studies in animals and humans agree that both forms of diabetes increase inflammatory events in periodontal tissue, impair new bone formation, and increase expression of RANKL in response to bacterial challenge. High levels of glucose, reactive oxygen species, and advanced glycation end‐products are found in the periodontium of diabetic individuals and lead to increased activation of nuclear factor‐kappa B and expression of inflammatory cytokines such as tumor necrosis factor and interleukin‐1. Studies in animals, moreover, suggest that there are multiple cell types in periodontal tissues that are affected by diabetes, including leukocytes, vascular cells, mesenchymal stem cells, periodontal ligament fibroblasts, osteoblasts, and osteocytes. The etiology of periodontal disease involves the host response to bacterial challenge that is affected by diabetes, which increases the expression of RANKL and reduces coupled bone formation. In addition, the inflammatory response also modifies the oral microbiota to render it more pathogenic, as demonstrated by increased inflammation and bone loss in animals where bacteria are transferred from diabetic donors to germ‐free hosts compared with transfer from normoglycemic donors. This approach has the advantage of not relying upon limited knowledge of the specific bacterial taxa to determine pathogenicity, and examines the overall impact of the microbiota rather than the presumed pathogenicity of a few bacterial groups. Thus, animal studies have provided new insights into pathogenic mechanisms that identify cause‐and‐effect relationships that are difficult to perform in human studies.

show abstract

mentioning

confidence: 99%

The impact of diabetes on periodontal diseases

Graves

Ding

Yang

2019

Periodontology 2000

237

172

View full text Add to dashboard Cite

show abstract

“…Strong evidence indicates that poorly controlled diabetes increases susceptibility to periodontitis, also known as diabetic periodontitis [2][3][4] . Patients with diabetic periodontitis exhibit greater alveolar bone loss and a poorer prognosis after routine treatments compared with patients who do not have diabetes [5] . Furthermore, some studies have revealed that an altered host immune response results in excessive inflammation and increases the severity of periodontal tissue destruction in diabetic periodontitis [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

et al. 2014

View full text Add to dashboard Cite

Aim: To investigate the therapeutic effects of resveratrol (RSV) on periodontitis in diabetic mice and to explore the underlying mechanisms in vitro. Methods: Experimental periodontitis was induced in db/db mice by ligature application of porphyromonas gingivalis. The mice were treated with RSV (20 mg/kg, po) daily for 4 weeks. Alveolar bone loss, proinflammatory cytokines and TLR4 expression in the gingival tissue were measured. Cultured gingival epithelial cells (GECs) were used for in vitro studies. The transcriptional activity of TLR4 downstream signaling was analyzed using Western blotting. Results: RSV administration significantly decreased the blood glucose levels, and ameliorated alveolar bone loss in db/db mice with experimental periodontitis. RSV administration also suppressed the high levels of IL-1β, IL-6, IL-8, TNF-α, and TLR4 in gingival tissue of the mice. In the GECs incubated in high glucose medium, TLR4 expression was substantially upregulated, which was partly blocked in the presence of RSV. Lipopolysaccharides markedly increased the expression and secretion of IL-1β, IL-6, IL-8, and TNF-α in the GECs cultured in high glucose medium, which was also partly blocked in the presence of RSV. Furthermore, RSV significantly suppressed the phosphorylation of TLR4 downstream factors NF-κB p65, p38MAPK, and STAT3. Conclusion: RSV exerts protective effects against experimental periodontitis in db/db mice via negative regulation of TLR4 signaling.

show abstract

“…An association between DM and CP has been reported, and DM is regarded as a risk factor for periodontitis (Kim et al , ; Soboku et al , ; Trivedi et al , ). Dysregulated TLR expression might be involved in DM, which can exacerbate CP.…”

Section: Tlrs In Cp With Systemic Diseasesmentioning

confidence: 99%

The role of Toll‐like receptors in periodontitis

et al. 2016

View full text Add to dashboard Cite

Periodontitis is a common infectious disease. Recent studies have indicated that the progression of periodontitis may be regulated by interactions between host immunity and periodontopathic bacteria. Although periodontopathic bacteria can destroy periodontal tissue, a dysfunctional host immune response triggered by the bacteria can lead to more severe and persistent destruction. Toll-like receptors (TLRs), a type of pattern recognition receptor (PRR) that recognizes pathogens, have been implicated in host innate immune responses to periodontopathic bacteria and in the activation of adaptive immunity. TLR-targeted drugs may hold promise to treat periodontal disease. This review summarizes recent studies on the role of TLRs in periodontitis and discusses areas needing further research. We believe TLRs may be an effective biomarker for the prevention, diagnosis, and treatment of periodontitis in the near future.

show abstract

Effect of the interaction between periodontitis and type 1 diabetes mellitus on alveolar bone, mandibular condyle and tibia

Cited by 25 publications

References 27 publications

The impact of diabetes on periodontal diseases

The impact of diabetes on periodontal diseases

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

The role of Toll‐like receptors in periodontitis

Contact Info

Product

Resources

About