Effect of the LT-α (+250 G/A) Polymorphism on Markers of Inflammation and Clinical Outcome in Critically Ill Patients

Abstract

There was no correlation between the biallelic LT-alpha (+250 G/A) polymorphism and the outcome of critically ill patients. Genotyping this locus does not seem to be useful in predicting sepsis outcome.

Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients

“…In the LTA (+250 G/A) analysis no association was observed corroborating the findings of Rauchschwalbe et al (2004) and Gong et al (2005). Furthermore, Schueller et al (2006) suggested the likelihood that this polymorphism does not serve as a prognostic marker for elevated sepsis risk in preterm infants.…”

Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis

“…This association was also found by other investigators [28], but others were unable to demonstrate an association between this polymorphism and outcome in patients with sepsis [11]. Similar contradictory findings have been reported in the case of TNF-β ( Nco I polymorphism); mortality in severe sepsis was higher in TNFB2 (AA) individuals [29,30], although other investigations found no such association [31]. A recent study enrolling 213 patients with severe sepsis [32] found no association between these polymorphisms and mortality.…”

Assessment of pretransplant inflammation in pediatric renal allograft recipients

“…Levels and the biological activity of many of the inflammatory markers in the body are known to be under significant genetic control. The same has been shown in the case of CRP, IL‐12, and Neo [16–18]. Polymorphisms in the genes controlling these inflammatory markers were not studied by us and could certainly have confounded our study results.…”