A roadway path is most commonly perceived as a 3-D element structure placed within its surrounding environment either within or outside urban areas. Design guidelines are usually strictly followed to ensure safe and comfort transportation of people and goods, but in full alignment with the terrain configuration and the available space, especially in urban and suburban areas. In the meantime, vehicles travelling along a roadway consume fuel and emit pollutants in a way that depends on both the driving attitude as well as the peculiar characteristics of road design and/or pavement surface condition. This study focuses on the environmental behavior of roadways in terms of fuel consumption, especially of heavy vehicles that mainly serve the purpose of freight transportation within urban areas. The impact of horizontal and vertical profiles of a roadway structure is theoretically considered through the parameters of speed and longitudinal slope, respectively. Based on theoretical calculations with an already developed model, it was found that the slope plays the most critical role, controlling the rate of fuel consumption increase, as an increase ratio of 2.5 was observed for a slope increase from 2% to 7%. The variation was less intense for a speed ranging from 25 to 45 km/h. The investigation additionally revealed useful discussion points for the need to consider the environmental impact of roadways during the operation phase for a more sustainable management of freight transportation procedures, thereby stimulating an ad hoc development of fuel consumption models based on actual measurements so that local conditions can be properly accounted for and used by road engineers and/or urban planners.