Effect of the metastatic defect on the structural response and failure process of human vertebrae: An experimental study

Alkalay, Ron N.

doi:10.1016/j.clinbiomech.2014.10.001

Cited by 24 publications

(43 citation statements)

References 54 publications

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“…Eighteen unembalmed lumbar vertebrae (L1-L5), obtained from five female donors aged 65-78 years, were recruited from a previous study (Alkalay, 2015) on the effect of lytic defects on the failure of human vertebrae. In that prior study, the lytic vertebra termed, Osteoporotic-lytic (OL), were to tested failure under combined compression and forward bending loads.…”

Section: Specimensmentioning

confidence: 99%

“…Polymethylmethacrylate cement (Vertebroplastic NH 9-44-20, Codman & Shurtleff, Inc, Raynham, MA) was prepared in accordance with the manufacturer's instruction and poured into several 1.0 cc (Alkalay, 2015), failed vertebral specimens with simulated lytic defect (OL-F) were augmented (OL-FA) and the change in vertebral structural competence quantified under mechanical loading. Changes in vertebral body dimensions with augmentation were similarly assessed.…”

Section: Vertebral Augmentation (Ol-fa)mentioning

confidence: 99%

“…The failed vertebrae termed, (OL-F), were allowed to recover under a preload of 200 N (simulating recumbence (Wilke et al, 1999) for a period of 30 min). The failed vertebrae were then retested to quantify their residual load carrying capacity (Alkalay, 2015). Prior to the creation of the defect (Fig.…”

Section: Specimensmentioning

confidence: 99%

“…Using pre-existing registration marks drawn using indelible ink to indicate the sagittal and transverse axis of the body (Alkalay, 2015), the augmented vertebra (OL-FA) was re-registered and mounted in a custom test device, Fig. 1.…”

Section: Mechanical Assessment Of Structural Competencementioning

confidence: 99%

“…In this study, eighteen human lumbar vertebrae were used from a previous study which investigated the effects of uncontained lytic defects on the failure process and residual load carrying capacity of the vertebrae using a wedge fracture model (Alkalay, 2015). The failed vertebrae underwent cement augmentation to investigate the biomechanical effectiveness of VA in restoring the mechanical competence of the failed vertebrae.…”

Section: Introductionmentioning

confidence: 99%

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Augmentation of failed human vertebrae with critical un-contained lytic defect restores their structural competence under functional loading: An experimental study

Alkalay

Stechow

Hackney

2015

Clinical Biomechanics

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Section: Specimensmentioning

confidence: 99%

Section: Vertebral Augmentation (Ol-fa)mentioning

confidence: 99%

Section: Specimensmentioning

confidence: 99%

Section: Mechanical Assessment Of Structural Competencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Augmentation of failed human vertebrae with critical un-contained lytic defect restores their structural competence under functional loading: An experimental study

Alkalay

Stechow

Hackney

2015

Clinical Biomechanics

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Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine

Alkalay

Harrigan

2016

Journal Orthopaedic Research

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To investigate the effects of a clinical lytic defect on the structural response of human thoracolumbar functional spinal unit. A novel CT-compatible mechanical test system was used to image the deformation of a T12-L1 motion segment and measure the change in strain response under compressive loads ranging from 50 to 750 N. A lytic lesion (LM) with cortex involvement (33% by volume) was introduced to the upper vertebral body and the CT experiments were repeated. Finite element models, established from the CT volumes, were used to investigate the defect's effects on the structural response and the state of principal and shear stresses within the affected and adjacent vertebrae. The lytic lesion resulted in severe loss of the vertebral structural competence, resulting in significant, non-linear, and asymmetric increase in the experimentally measured strains and computed stresses within both vertebrae (p < 0.01). At the cortex, the tensile strains were significantly increased, while compressive strains significantly decreased, (p < 0.05). Both the vertebral bone and cortex regions adjacent to the defect showed significant increase in computed compressive, tensile, and shear stresses (p < 0.01). Changes in stress and strain distribution within the affected and adjacent vertebral bone and the experimentally observed bulging and buckling of the vertebral cortices suggested that initiation of catastrophic vertebral failure may occur under load magnitudes encountered in daily living. Although the effect of LM on the global deformation of the spine was well-predicted, our results show that FE predictions of local strain changes must be carefully assessed for clinical relevance. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1808-1819, 2016.

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High-intensity exercise did not cause vertebral fractures and improves thoracic kyphosis in postmenopausal women with low to very low bone mass: the LIFTMOR trial

Watson

Weeks

Weis³

et al. 2019

Osteoporos Int

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Effect of the metastatic defect on the structural response and failure process of human vertebrae: An experimental study

Cited by 24 publications

References 54 publications

Augmentation of failed human vertebrae with critical un-contained lytic defect restores their structural competence under functional loading: An experimental study

Augmentation of failed human vertebrae with critical un-contained lytic defect restores their structural competence under functional loading: An experimental study

Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine

High-intensity exercise did not cause vertebral fractures and improves thoracic kyphosis in postmenopausal women with low to very low bone mass: the LIFTMOR trial

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