Effect of the mixed herbal medicines extracts on menopausal symptoms: A randomized clinical trial study

Abstract

Background: Menopause cause many symptoms, which may impair quality of life the women. The study aims to determine the effectiveness of mixed herbal medicinal extracts on menopausal symptoms. Method: A randomized, triple-blind, placebo-controlled clinical trial was conducted on 120 peri-menopausal women for 12 weeks. All participants took herbal extracts drops orally daily. They were randomly allocated into four groups: placebo (C), A (250 mg chamomile, 30 mg fennel, 15 mg saffron), B (1000 mg chamomile, 120 mg fennel, 60 mg saffron), and D (500 mg chamomile, 60 mg fennel, 30 mg saffron).They completed a demographic and MRS questionnaire at week 0, 6.12. Result: 108 participants successfully completed the assessment. No significant differences in demographic variables were seen between the four groups. The median MRS score was significantly reduced in group B from 27.5±3 to 7.5±5. In group D, it was significantly reduced from 29±12 to 22±9.25The effect size in this study was 0.92. Conclusion: Study showed significant improvement in menopausal symptoms especially in group B.

Interventions to Reduce Menopause Signs and Symptoms in Menopause Women a Narrative Review

“…Fitoestrogen adalah senyawa non steroid yang terdapat pada tumbuhan yang memiliki efek estrogenik. Berikut ini merupakan beberapa intervensi penggunaan tumbuhan (herbal) sebagai fitoestrogen, diantaranya kombinasi 1000 mg chamomile, 120 mg adas, dan 60 mg saffron (Minenko, et al, 2019;Mahdavian, et al, 2019), ekstrak Rubus coreanus Miq. dan ekstrak Bunge Astragalus membranaceus (Park et al, 2022), kapsul ginseng merah Korea (Chung, et al, 2020), dan suplemen Jazar (Hafizi, et al, 2021).…”