1986
DOI: 10.1016/0168-9452(86)90124-x
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Effect of the natural algicide, cyanobacterin, on a herbicide-resistant mutant of anacystis nidulans R2

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Cited by 29 publications
(8 citation statements)
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“…The minimum concentration to inhibit the electron transport in PS  was lower than that of the typical PS  inhibitor, 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). However further studies with the herbicide-resistant mutant showed that the binding site of 1 was diŠerent from that of DCMU 5,6) and suggested that 1 acted on another site in PS . Synthesized racemic 1 7) has been tested for its biological activity and found to need twice the minimum dose required of with natural compound.…”
mentioning
confidence: 99%
“…The minimum concentration to inhibit the electron transport in PS  was lower than that of the typical PS  inhibitor, 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). However further studies with the herbicide-resistant mutant showed that the binding site of 1 was diŠerent from that of DCMU 5,6) and suggested that 1 acted on another site in PS . Synthesized racemic 1 7) has been tested for its biological activity and found to need twice the minimum dose required of with natural compound.…”
mentioning
confidence: 99%
“…This cyanobacterium specifically inhibits a wide range of microalgae, including cyanobacteria and green algae, with concentrations on the order of micromolar of cyanobacterin [97]. Its mode of action is mainly based on the inhibition of photosystem II [68,98,99].…”
Section: Alkaloidsmentioning
confidence: 99%
“…Cyanobacterin (1) thereby seems to target a different binding site than DCMU, since DCMU-resistant mutants are still sensitive to 1. 6,7 Interestingly, the anhydro isomer 3 2 resulting from dehydratation of 1, lacks this biological activity. 4 Owing to its strong biological activity, 1 is a promising lead structure for the development of potent phytotoxins, for example, for agrochemical applications.…”
mentioning
confidence: 99%
“…Overall, this led to a general paradigm for furanolide biosynthesis and the discovery of unprecedented C,C-bond forming biochemistry facilitated by the first bona fide Morita-Baylis-Hillman (MBH) reaction catalyzing biosynthetic enzyme. 1), its anhydro analog 2, a selection of related furanolide natural productsnostoclide I (3), enhygrolide (4), angiolactone (5)and the common furanolide core structure (6). Former C--positions of putative amino acid precursor are indicated by colored dots.…”
mentioning
confidence: 99%
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