Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen

Pedroso, Fiona L.; Fávero, Giovani Marino; Camargo, Luciana Erzinger Alves de; Mainardes, Rubiana Mara; Khalil, Najeh Maissar

doi:10.3109/14756366.2012.680064

Cited by 26 publications

(15 citation statements)

References 29 publications

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“…The antitumor activity of TAM was evidenced by the reduction in the relative tumor size compared with untreated tumor-bearing control animals. This observation is in agreement with the previously reported cytotoxicity of TAM on MCF-7 and MDA-MB-231 human breast cancer cells (Al-Akoum et al, 2007), OC2 human oral cancer cells (Chu et al, 2007), human epidermal keratinocyte cell line (Bhatia et al, 2010), human chronic myeloid leukemia (K562) cell line (Pedroso et al, 2013). Allicin produced a reduction in relative tumor size supporting the well-established antitumor effect of allicin against a variety of tumors in preclinical models (Padilla-Camberos et al, 2010;Patya et al, 2004).…”

Section: Discussionsupporting

confidence: 82%

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Suddеk

2014

Pharmaceutical Biology

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Context: Tamoxifen (TAM) is widely used for treatment of hormone-dependent breast cancer; however, it may be accompanied with hepatic injury. Allicin is the most abundant thiosulfinate molecule from garlic with the potential to provide beneficial effects on various diseases. Objective: To elucidate the effect of commercially available allicin on both antitumor activity and liver injury of TAM. Materials and methods: The cytotoxicity of TAM and/or allicin was evaluated in vitro using cultured Ehrlich ascites carcinoma (EAC) cells and in vivo against murine tumor (solid) model of EAC. TAM induced liver injury in rats by intraperitoneally (i.p.) injection at a dose of 45 mg/kg, for 7 successive days.Results: TAM at a dose of 3 mM (IC 50 ) significantly decreased percent survival of EAC to 52%. TAM combination with allicin (5 or 10 mM) showed a significant cytotoxic effect compared with the TAM-treated group as manifested by a decrease in percent survival of EAC to 35% and 29%, respectively. Allicin (10 mg/kg, orally) enhanced the efficacy of TAM (1 mg/kg, i.p.) in mice as manifested by a significant increase in solid tumor growth inhibition by 82% compared with 70% in the TAM group. In rats, TAM intoxication resulted in a significant decline in SOD, GSH, and total protein with significant elevation in TBARS, ALT and AST, ALP, LDH, total bilirubin, gGT, and TNF-a levels. These changes are abrogated by allicin treatment. Discussion and conclusion: The results suggest the beneficial role of allicin as an adjuvant to TAM in cancer treatment by alleviating liver injury.

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Section: Discussionsupporting

confidence: 82%

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Suddеk

2014

Pharmaceutical Biology

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“…Vanillin is found in several essential plant oils, principally Vanilla planifolia , Vanilla tahitensis, and Vanilla pompona [8]; it is often found in processed foods, beverages, and pharmaceutical products and also in perfumery [9, 10]. Vanillin has antioxidant and antitumor potential [11], and it is reported that its activity might be more beneficial for daily health care than had been previously thought [12]. A rich diet in such radical scavengers could reduce free radical cancer promotion [13].…”

Section: Introductionmentioning

confidence: 99%

Overview of the Role of Vanillin on Redox Status and Cancer Development

Bezerra

Soares

Sousa

2016

Oxidative Medicine and Cellular Longevity

106

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Bioactive natural products play critical roles in modern drug development, especially anticancer agents. It has been widely reported that various pharmacological activities of such compounds are related to their antioxidant properties. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Considering the importance of vanillin in the area of human health and food and pharmaceuticals sectors, in this review, we discuss the role of vanillin on redox status and its potential contribution to the prevention and the treatment of cancer.

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“…Cancer is considered a public health problem in developed and developing countries (Guerra et al, 2005;Pedroso et al, 2013). Tamoxifen (TMX), a selective estrogen receptor modulator and non-steroidal antiestrogenic drug, is used in the chemotherapy of breast cancer (Kuo et al, 2012;Tsai et al, 2014;Pandey et al, 2016) but many studies reported that tamoxifen in toxic doses lead to oxidative liver ., 1993) and its adverse effects, such as hot flashes, fatty liver, et al damage (Hard ., 2017).It et al ., 2014; Wickramage et al Ribeiro and hepatocarcinomas ( hepatotoxicity may be more toxic to liver because it has higher affinity for hepatic tissue than for any other tissues (Desai et al, 2002), therefore this study was conducted in order to investigate the role of MAE, as food supplement or pro-drug, in reducing Tamoxifen ® side effects through studying of its antioxidant and protective potential against the Tamoxifen-induced toxicities in male albino rats.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Moringa oleifera Aqueous Extract in Inhibiting Tamoxifen®-Induced Physiological Hepatic Deterioration in Male Albino Rats.

Essawy

Beeker

Abdel-Wahhab

et al. 2017

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen

Cited by 26 publications

References 29 publications

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Overview of the Role of Vanillin on Redox Status and Cancer Development

Efficacy of Moringa oleifera Aqueous Extract in Inhibiting Tamoxifen®-Induced Physiological Hepatic Deterioration in Male Albino Rats.

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