Effect of the Opioid Peptide Beta-Endorphin on the in vivo Release of Vasopressin in Rats under Various Conditions

Haaf, Jeroen Alexander ten; Greidanus, T.B. van Wimersma; Maigret, C.; Wied, D. de

doi:10.1159/000124629

Cited by 28 publications

(5 citation statements)

References 22 publications

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“…17 However, the inhibitory effect of leumorphin was much greater than that of /3-endorphin or leu-enkephalin, 14 " 16 and was comparable to that of dynorphin. 17 In addition, the inhibitory action of leumorphin was observed within 5 minutes after i.c.v.…”

Section: Discussionmentioning

confidence: 94%

“…injection, whereas /3-endorphin was reported to inhibit AVP secretion 30 minutes later. 16 Thus, the inhibitory effect of leumorphin on AVP secretion is rapid as well as potent. Furthermore, leumorphin, dynorphin, and neoendorphin sharing the same precursor (proenkephalin B) coexist with AVP in magnocellular neurons in the supraoptic and paraventricular nuclei, 8 and relatively dense K-opioid receptors are present in the rat hypothalamus 18 and pituitary."…”

Section: Discussionmentioning

confidence: 99%

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Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.

et al. 1988

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TAKAYUKI YAMADA, KAZUWA NAKAO, HIROSHI ITOH, NARITO MORII, SHOZO SHIONO, MAKOTO SAKAMOTO, AKIRA SUGAWARA, YOSHIHIKO SAITO, MASASHI MUKOYAMA, HIROSHI ARAI, AND HIROO IMURA SUMMARY The effects of leumorphin, a K-agonist derived from proenkephalin B (neoendorphin and dynorphin precursor), on vasopressin secretion were studied under basal and stimulated conditions in conscious, unrestrained rats. Intracerebroventricular injection of leumorphin (60 or 600 pmol) significantly inhibited basal vasopressin secretion. The vasopressin response induced by intracerebroventricular injection of angiotensin II (100 pmol) was significantly suppressed, hi a dose-dependent fashion, by the simultaneous intracerebroventricular injection of leumorphin (6, 60, or 600 pmol). Intravenous pretreatment with naloxone (0.5 mg/kg body weight) diminished the inhibitory action of leumorphin (60 pmol) on vasopressin secretion. Moreover, naloxone (0.5 mg/kg body weight) prolonged the vasopressin secretion induced by intracerebroventricular injection of angiotensin II (100 pmol). These results indicate that leumorphin possesses a potent inhibitory effect on vasopressin secretion and that, alone or in combination with other endogenous opioid peptides, it plays an important role hi the control of vasopressin secretion. 1 -2 Using a specific radioimmunoassay (RIA) for leumorphin coupled with high performance liquid chromatography, we demonstrated the presence of leumorphin in the pituitary and brain, 3 -4 and parallel distribution of leumorphin and dynorphin in discrete regions of the brain. 3 We also reported that leumorphin acts as an agonist at the K-type opioid receptor, 6 and that intracerebroventricular (i.c.v.) injection of leumorphin inhibits water drinking induced by water deprivation, angiotensin II (Ang II), or carbachol in rats, which suggests its involvement in the central control of water and electrolyte balance. 7 In addition, dynorphin derived from the same precursor as that of leumorphin

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.

et al. 1988

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“…As mentioned before hypo tension and bradycardia have been observed after the cen tral administration of [3-endorphin and dynorphin(l-13). After intraventricular administration (3-endorphin as well as dynorphin] 1-13) caused a decrease in the immunoreacti vity of vasopressin in plasma [43,44]. The in vitro release of (3-endorphin and dynorphin from rat hypothalamic slices is stimulated by corticotropin-releasing factor [25] and the precursor molecules pro-opiomelanocortin and pro-enke phalin B, respectively, for (3-endorphin and dynorphin are both located in the NTS and in the arcuate nucleus of the basal hypothalamus [18].…”

Section: Discussionmentioning

confidence: 99%

Possible Involvement of Beta Endorphin(1–31) and Dynorphin(1–13) in the Central Hypotensive Mechanism of Action of Alpha Methyldopa

Giersbergen

Wiegant

Jong³

1989

Neuroendocrinology

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The present study was performed to gain more information on the nature of the opioid peptide(s) involved in the mechanism of action of α-methyldopa. Conscious, normotensive Wistar rats were used and all treatments were given intracisternally. For blood pressure and heart rate, pretreatment with a midportion β-endorphin antiserum resulted in a parallel shift to the right of the dose-response curve for α-methyldopa. In addition, when rats were pretreated with various dilutions of this antiserum and treated with a constant dose of α-methyldopa, the antiserum dose-dependently inhibited α-methyldopa-induced hypotension and bradycardia. Using antisera specifically recognizing the C-terminus of β-, γ- and α-endorphin, respectively, revealed that only the β-endorphin antiserum inhibited the decrease in blood pressure seen after administration of α-methyldopa. An antiserum against [Met⁵]enkephalin did not influence the cardiovascular responses following α-methyldopa. On the other hand, a dynorphin(1–13) antiserum also inhibited in a dose-dependent manner the hypotension induced by α-methyldopa. When administered 3 h after the injection of α-methyldopa, the β-endorphin and dynorphin(1–13) antisera failed to reverse the hypotension induced by α-methyldopa. The results favor a role for β-endorphin(1-31) and dynorphin(l-13) in the hypotension centrally mediated by α-methyldopa.

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“…Because of the short half life of VP in the blood, blood was taken from a forearm vein immediately after each csf drainage. The plasma and csf were stored at -20 °C until the VP concentration was measured by radioimmunoassay {Ten Haaf, Van Wimersma Greidanus, Maigret and De Wied 1986). In short, the plasma was extracted with activated Vycor (Corning Glass Works, New York).…”

Section: Case Reportmentioning

confidence: 99%

Inverse Relationship Between Plasma Vasopressin and Intracranial Pressure

et al. 1992

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Effect of the Opioid Peptide Beta-Endorphin on the in vivo Release of Vasopressin in Rats under Various Conditions

Cited by 28 publications

References 22 publications

Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.

Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.

Possible Involvement of Beta Endorphin(1–31) and Dynorphin(1–13) in the Central Hypotensive Mechanism of Action of Alpha Methyldopa

Inverse Relationship Between Plasma Vasopressin and Intracranial Pressure

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