Effect of the PAF-Antagonist SRI 63–441 on the Allergic Reaction in Awake Dogs with Natural Asthma

Stenzel, H; Hummer, B. Timothy; Hl, Hahn

doi:10.1007/978-3-0348-7451-9_23

Cited by 3 publications

(1 citation statement)

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“…One re port documents that a PAF antagonist does not alter an allergen-induced airway response in dogs with As caris airway reactivity [22], The current studies were done because if both agonists are released or gener ated during IgE-mediated airway reactions a single receptor antagonist might be insufficient to show in hibitory activity. Combinations of both receptor anta gonists might, in theory, inhibit the Ascaris antigen airway response.…”

Section: Reproducibility Of Resultsmentioning

confidence: 99%

Effects of Combined Receptor Antagonists of Leukotriene D4(LTD4) and Platelet-Activating Factor (PAF) on Rhesus Airway Responses to LTD4, PAF and Antigen

Patterson

Harris

Bernstein

et al. 1989

Int Arch Allergy Immunol

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Rhesus monkeys with IgE-mediated asthmatic-type responses to Ascaris suum antigen were pre-treated with a combination of 2 receptor antagonists to leukotriene D₄ (LTD₄) and platelet-activating factor (PAF). This combination of anti-LTD₄ and anti-PAF was shown to inhibit airway responses to either LTD₄ or PAF in separate experiments in these Ascaris airway-reactive animals. When the same combination of LTD₄and PAF receptor antagonists was used to pretreat the same animal prior to aerosol challenge with Ascaris antigen we could not demonstrate inhibition of the antigen-induced airway response. Thus, combined receptor blockade for LTD₄ and PAF did not alter IgE-mediated acute airway responses to antigen in this species. We review the current status of rhesus asthma and LTD₄ and PAF receptor antagonist activity in this model.

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Section: Reproducibility Of Resultsmentioning

confidence: 99%