Effect of the pneumococcal conjugate vaccine on pneumococcal carriage in Turkish children

Ercan, Tuğba Erener; Severge, Burcu; Topkaya, Aynur Eren; Ercan, R. Goekmen; Altinkaya, Nuevit

doi:10.1111/j.1442-200x.2010.03212.x

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…In the Murad study, 63% of subjects were exposed to cigarette smoke, whereas in this study, 78-86.1% had been exposed. The prevalence of subjects who experienced pneumococcal colonization in this study was also higher than those found in studies in Finland (9%) and Turkey (9.7%) [22,23]. However, the prevalence was still lower than in subjects six weeks of age in Ethiopia in 2013 (32.7%) [24].…”

Section: Plos Onecontrasting

confidence: 64%

Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study

et al. 2021

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Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of PCV13 demonstration program by the Indonesian Ministry of Health in Lombok Island, West Nusa Tenggara, Indonesia, from March 2018 to June 2019. The subjects were two-month-old healthy infants who were brought to the primary care facility for routine vaccination and followed until 18 months of age. We use convenience sampling method. There were 115 infants in the control group and 118 infants in the vaccine group, and the PCV immunization was given on a 2+1 schedule. Nasopharyngeal (NP) swabs were collected four times during the vaccination periods by trained medical staff. Specimens were analyzed by culture methods to detect S. pneumonia colonization and multiplex polymerase chain reaction (mPCR) to determine serotype. The most frequently detected serotypes will be named as dominant serotypes. Descriptive analysis of demographic characteristics, the prevalence of overall and serotype colonization, and the distribution of serotypes were performed. The prevalence of both cohort groups were compared using chi-square test. Statistical significance was set at p < 0.05. Results Two hundred and thirty three infants age two months old were recruited, with 48.9% of the subjects were male and 51.1% of the subjects were female. Sociodemographic data in both cohort groups were relatively equal. Nasopharyngeal pneumococcal colonization before PCV13 administration occurred in 19.1% of the control and 22.9% of the vaccine group. The prevalence increased with increasing age in both groups. The prevalence of VT serotypes in control groups aged 2 months, 4 months, 12 months, and 18 months was 40.9%, 44.2%, 53.8%, and 54.3%, respectively, and in the vaccine group, 25.9%, 40.4%, 38.0%, and 22.6%, respectively. The most common VT serotypes in both groups were 6A/6B, 19F, 23F, and 14. The prevalence of VT serotypes decreased significantly compared to non-vaccine type serotypes after three doses of the PCV13 vaccine (p < 0.001). Another notable change was the decline in prevalence of serotype 6A/6B after PCV13 administration using the 2+1 schedule. Conclusions This study shows lower prevalence of VT and 6A/6B serotypes in the nasopharynx among children who were PCV13 vaccinated compared with those who were unvaccinated. The result from this study will be the beginning of future vaccine evaluation in larger population and longer period of study.

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Section: Plos Onecontrasting

confidence: 64%

Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study

et al. 2021

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“…Similarly, a study by Ercan et al. 93 from Turkey, reported on the resistance of S. pneumoniae to TMP-SMX at 63.3% followed by erythromycin at 40% and tetracycline at 33.3%. A study by Shibl et al.…”

Section: Prevalencementioning

confidence: 82%

Epidemiology of community-acquired pneumonia and implications for vaccination of children living in developing and newly industrialized countries: A systematic literature review

DeAntonio

Yarzábal

Cruz³

et al. 2016

Human Vaccines & Immunotherapeutics

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This systematic review evaluated the epidemiology of community-acquired pneumonia in children <6 y of age within 90 developing and newly industrialized countries. Literature searches (1990–2011), based on MEDLINE, EMBASE, Cochrane, CAB Global Health, WHO, UNICEF, country-specific websites, conferences, health-technology-assessment agencies, and the reference lists of included studies, yielded 8,734 records; 62 of 340 studies were included in this review. The highest incidence rate among included studies was 0.51 episodes/child-year, for children <5 y of age in Bangladesh. The highest prevalence was in Chinese children <6 months of age (37.88%). The main bacterial pathogens were Streptococcus pneumoniae, Haemophilus influenzae and Mycoplasma pneumoniae and the main viral pathogens were respiratory syncytial virus, adenovirus and rhinovirus. Community-acquired pneumonia remains associated with high rates of morbidity and mortality. Improved and efficient surveillance and documentation of the epidemiology and burden of community-acquired pneumonia across various geographical regions is warranted.

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“…The rate of intermediate resistance to penicillin reportedly ranged between 0% and 76.7%, and penicillin resistance ranged between 0% and 11.5%. The NP pneumococcal carriage rate among penicillin non-susceptible isolates (PNS, intermediate and resistant) reportedly ranged between 0% and 86.7% among healthy Turkish children before the introduction of the PCV [19][20][21][22][23]33,34]. In the present study, the PNS rate was 60%; Ozdemir et al [25] noted a 73% PNS rate (intermediate, 50.6%, and resistant, 22.4%) during the early post-PCV7 period.…”

Section: Discussionmentioning

confidence: 99%

The impact of a pneumococcal conjugate vaccination program on the nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among healthy children in Turkey

Soysal

Karabağ-Yılmaz

Kepenekli

et al. 2016

Vaccine

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Effect of the pneumococcal conjugate vaccine on pneumococcal carriage in Turkish children

Cited by 7 publications

References 31 publications

Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study

Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study

Epidemiology of community-acquired pneumonia and implications for vaccination of children living in developing and newly industrialized countries: A systematic literature review

The impact of a pneumococcal conjugate vaccination program on the nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among healthy children in Turkey

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