Effect of the Pro-Gly-Pro peptide on resistance of rats to acute hypobaric hypoxia and posthypoxic behavioral disorders

Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

“…PGP unites the characteristics of a D 2 receptor antagonist with the neuroprotective [6,9] and nootropic [5] effects, and hence, can be regarded as a candidate antipsychotic drug effective for therapy of positive symptoms and cognitive disorders in schizophrenia and other psychoses.…”

“…These characteristics are assumed to be essential for the realization of other effects of glyprolines, for example, their antiulcerogenic effect on the gastric mucosa under conditions of stress inducing ulcer formation [8]. In addition, PGP exhibited a neuroprotective effect in vitro on nerve cell culture under conditions of oxidative stress [6] and in vivo on hypoxic animals [9]. Presumably, the effect of PGP on hypoxic resistance is due to blood fl ow stimulation and more rapid saturation of tissues with oxygen as a result of glyproline preinjection.…”