Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis

Ranuh, Reza Gunadi; Athiyyah, Alpha Fardah; Darma, Andy; Risky, Vitria Prasetyo; Riawan, Wibi; Surono, Ingrid S.; Sudarmo, Subijanto Marto

doi:10.18502/ijm.v11i2.1077

Cited by 53 publications

(47 citation statements)

References 26 publications

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“…Hypothalamic-pituitary-adrenal axis (HPA) modification [27] Neurotransmitter synthesis (such as gamma aminobutyric acid, serotonin, dopamine, noradrenaline, melatonin, histamine and acetylcholine) [28][29][30] Modulation of brain-derived neurotrophic factor (BDNF) [31] Modulation of oxytocin [32] Interaction with the 10th cranial nerve (nervus vagus) [33] Postbiotics (such as short chain fatty acids) [34,35] Preservation/improvement of the intestinal barrier function [36] Training of the immune system, immunomodulation [37] Suppression of pathogens [38] Shaping of neural networks [39] However, mood effects are only significant in participants exhibiting symptoms of depression [72]. Currently, there are five probiotic RCTs using predominantly Lactobacillus and Bifidobacterium species to treat depression (see Table 1).…”

Section: Mechanisms Of Psychobiotic Actionmentioning

confidence: 99%

Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry

et al. 2020

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Purpose of Review Probiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gut microbes are suggested to play a role in many psychiatric disorders and could be a potential therapeutic target. Between the gut and the brain, there is a bi-directional communication pathway called the microbiota-gut-brain axis. The purpose of this review is to examine data from recent interventional studies focusing on probiotics and the gut-brain axis for the treatment of depression, anxiety and schizophrenia. Recent Findings Probiotics are likely to improve depression but not schizophrenia. Regarding anxiety, there is only one trial which showed an effect of a multispecies probiotic. However, determinants like the duration of treatment, dosage and interactions have not been thoroughly investigated and deserve more scientific attention. Summary Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis.

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Section: Mechanisms Of Psychobiotic Actionmentioning

confidence: 99%

Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry

et al. 2020

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“…Similarly, the species has been shown to modulate µ-opioid receptor expression and activity, which has been suggested as a mechanism for the reduction of bloating in adults with functional abdominal pain [46,47]. More recently, Lactobacillus was shown to upregulate expression of both serotonin transporter and intestinal serotonin levels [48], which further suggests a potential gut-brain role. In addition to the regulation of pain, mental stress was decreased with L. acidophilus DDS-1 in the current study.…”

Section: Discussionmentioning

confidence: 97%

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial

Martoni¹,

Srivastava

Leyer³

2020

Nutrients

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This randomized, double-blind, placebo-controlled, multi-center study investigated the clinical efficacy of two probiotic strains on abdominal pain severity and symptomology in irritable bowel syndrome (IBS). Three hundred and thirty adults, aged 18 to 70 years, with IBS according to Rome IV criteria were allocated (1:1:1) to receive placebo, Lactobacillus acidophilus DDS-1 (1 × 1010 CFU/day) or Bifidobacterium animalis subsp. lactis UABla-12 (1 × 1010 CFU/day) over six weeks. The primary outcome was the change in Abdominal Pain Severity - Numeric Rating Scale (APS-NRS). Over the intervention period, APS-NRS was significantly improved in both probiotic groups vs. placebo in absolute terms (DDS-1: −2.59 ± 2.07, p = 0.001; UABla-12: −1.56 ± 1.83, p = 0.001) and in percentage of significant responders (DDS-1: 52.3%, p < 0.001); UABla-12 (28.2%, p = 0.031). Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for L. acidophilus DDS-1 (−133.4 ± 95.19, p < 0.001) and B. lactis UABla-12 (−104.5 ± 96.08, p < 0.001) groups, including sub-scores related to abdominal pain, abdominal distension, bowel habits and quality of life. Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo. In conclusion, L. acidophilus DDS-1 and B. lactis UABla-12 improved abdominal pain and symptom severity scores with a corresponding normalization of bowel habits in adults with IBS.

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“…The arachidonic acid has an immune-enhancing effect [64]. Enteroendocrine cells within the mucosal lining of the gut synthesize and secrete a number of hormones including 5-HT, which have regulatory roles in key metabolic processes such as insulin sensitivity, glucose tolerance, fat storage, and appetite [61,65,66]. Gutderived 5-HT in shaping gut microbiota composition in relation to susceptibility to colitis, identifying 5-HT-microbiota axis as a potential new therapeutic target in intestinal inflammatory [67].…”

Section: Discussionmentioning

confidence: 99%

Seasonal Dynamics and Starvation Impact on the Gut Microbiome of Urochordate Ascidian Halocynthia roretzi

Wei

Gao²,

Yang

et al. 2020

Preprint

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BackgroundGut microbiota plays important roles in host animal physiology, homeostasis, metabolism, and environmental adaptation while the interplay between the gut microbiome and urochordate ascidian, the most closet relative of vertebrate, remains less explored. In this study, we characterized the gut microbial communities of urochordate ascidian (Halocynthia roretzi) across the changes of season and starvation stress using a comprehensive set of omic approaches including 16S rRNA, metagenomic, metabiotic, and transcriptome sequencing.ResultsThe 16S rRNA amplicon profiling revealed that ascidians harbor indigenous gut microbiota distinctly different to the marine microbial community and significant variations in composition and abundance of gut bacteria, with predominant bacterial orders representing each season. Depressed alpha-diversities of gut microbiota were observed across starvation stress when compared with the communities in aquafarm condition. Synechococcales involving photosynthesis and its related biosynthesis was reduced in abundance while the enrichments of Xanthomonadales and Legionellales may facilitate bile acid biosynthesis in starvation stress condition. Meanwhile, the metabolomics analysis found that the long chain fatty acids, linolenic acid, cyanoamino acid, and pigments derived from gut bacteria were upregulated, suggesting a beneficial contribution of the gut microbiome to ascidian under starvation stress.ConclusionsOur results revealed the seasonal variation of ascidian gut microbiota. Furthermore, we found that the defense and energy-associated metabolites derived from gut microbiome were responded to the starvation stress. The data provide insights into understanding the adaptive interplay between the gut microbiome and ascidian host that maintains a beneficial metabolic system across season and starvation stress. The diversity-generating metabolisms from both microbiota and host might lead to the co-evolution and environmental adaptation.

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Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis

Cited by 53 publications

References 26 publications

Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry

Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial

Seasonal Dynamics and Starvation Impact on the Gut Microbiome of Urochordate Ascidian Halocynthia roretzi

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