Effect of the Progression of Fusobacterium nucleatum–induced Apical Periodontitis on the Gut Microbiota

Haraga, Hiroshi; Satoh, Takenori; Watanabe, Koichi; Hamada, Naoki; Tani‐Ishii, Nobuyuki

doi:10.1016/j.joen.2022.04.014

Cited by 12 publications

(5 citation statements)

References 32 publications

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“… Objects Groups Duration Application Samples α diversity β diversity Phylum Genus 8w C57BL/6J mice [ 32 ] Aggregatibacter actinomycetemcomitans vs . control 6 × per week for 6 weeks 10 8 CFU by oral gavage Feces No No Turicibacter↓ 3w female Wistar rats [ 33 ] Fusobacterium nucleatum vs . control 2 w, 4 w, 8 w 3.6 × 10 11 CFU/ml in the open pulp to induce apical periodontitis Rectum Proteobacteria↑ Firmicutes↑ Bacteroidetes↓ Verrucomicrobia↓ Akkermansia muciniphila ↓ 8w male C57BL/6 mice [ 34 ] Streptococcus mitis vs .…”

Section: Factors Of Oral Microbiota To Affect Gut Microbiotamentioning

confidence: 99%

“…Fusobacterium nucleatum ( F. nucleatum ), which is involved in the development of periodontal disease and apical lesions, has been reported to affect the gut microbiota. After inducing apical periodontitis in rat molars by infecting the dental pulp with F. nucleatum , F. nucleatum can be detected in the gut at 2 weeks, and change gut microbiota, with confirmed infection in the large intestines [ 33 ].…”

Section: Factors Of Oral Microbiota To Affect Gut Microbiotamentioning

confidence: 99%

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The interplay between oral microbiota, gut microbiota and systematic diseases

Tan

Wang²,

Gong

2023

Journal of Oral Microbiology

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Over the past two decades, the importance of microbiota in health and disease has become evident. The human gut microbiota and oral microbiota are the largest and second-largest microbiome in the human body, respectively, and they are physically connected as the oral cavity is the beginning of the digestive system. Emerging and exciting evidence has shown complex and important connections between gut microbiota and oral microbiota. The interplay of the two microbiomes may contribute to the pathological processes of many diseases, including diabetes, rheumatoid arthritis, nonalcoholic fatty liver disease, inflammatory bowel disease, pancreatic cancer, colorectal cancer, and so on. In this review, we discuss possible routes and factors of oral microbiota to affect gut microbiota, and the contribution of this interplay between oral and gut microbiota to systemic diseases. Although most studies are association studies, recently, there have been increasing mechanistic investigations. This review aims to enhance the interest in the connection between oral and gut microbiota, and shows the tangible impact of this connection on human health.

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Section: Factors Of Oral Microbiota To Affect Gut Microbiotamentioning

confidence: 99%

Section: Factors Of Oral Microbiota To Affect Gut Microbiotamentioning

confidence: 99%

The interplay between oral microbiota, gut microbiota and systematic diseases

Tan

Wang²,

Gong

2023

Journal of Oral Microbiology

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“…Moreover, in a rodent model of periodontitis induced by F. nucleatum, researchers detected the migration of oral bacteria to the intestinal tract, concomitant with shifts in the gut microbiota. Specifically, the gut ecosystem exhibited modifications, with a notable reduction in Verrucomicrobia and an elevation in Proteobacteria evident within a two-week timeframe, followed by subsequent increases in Bacteroidetes and Firmicutes observed to the four-week time point [133]. For in vivo study on the C57BL/6 mouse strain, the amount of Klebsiella and Enterobacter species in the oral cavity and intestine increased in periodontitis; pathobionts promoted Th17 cell activation and colitis development [134].…”

Section: Oral Bacteria and Scfas Production In The Gutmentioning

confidence: 99%

The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review

Leonov,

Varaeva,

Livantsova

et al. 2023

Biomedicines

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The human oral microbiome has emerged as a focal point of research due to its profound implications for human health. The involvement of short-chain fatty acids in oral microbiome composition, oral health, and chronic inflammation is gaining increasing attention. In this narrative review, the results of early in vitro, in vivo, and pilot clinical studies and research projects are presented in order to define the boundaries of this new complicated issue. According to the results, the current research data are disputable and ambiguous. When investigating the role of SCFAs in human health and disease, it is crucial to distinguish between their local GI effects and the systemic influences. Locally, SCFAs are a part of normal oral microbiota metabolism, but the increased formation of SCFAs usually attribute to dysbiosis; excess SCFAs participate in the development of local oral diseases and in oral biota gut colonization and dysbiosis. On the other hand, a number of studies have established the positive impact of SCFAs on human health as a whole, including the reduction of chronic systemic inflammation, improvement of metabolic processes, and decrease of some types of cancer incidence. Thus, a complex and sophisticated approach with consideration of origin and localization for SCFA function assessment is demanded. Therefore, more research, especially clinical research, is needed to investigate the complicated relationship of SCFAs with health and disease and their potential role in prevention and treatment.

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“…Bacterial migration occurs via three primary pathways: The enteral route, the hematogenous route, and immune cell migration[ 7 ]. Notable periodontal pathogens, such as Porphyromonas gingivalis ( P. gingivalis ), Fusobacterium nucleatum , and Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ), significantly affect the gut microbiota[ 8 - 10 ]. Conversely, by altering the gut ecosystem, oral dysbiosis may intensify chronic liver diseases, such as NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional role of oral bacteria in the progression of non-alcoholic fatty liver disease

Mei,

Yao,

Chen

et al. 2024

World J Hepatol

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Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders of varying severity, ultimately leading to fibrosis. This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis. The pathogenesis of NAFLD is closely associated with disturbances in the gut microbiota and impairment of the intestinal barrier. Non-gut commensal flora, particularly bacteria, play a pivotal role in the progression of NAFLD. Notably, Porphyromonas gingivalis , a principal bacterium involved in periodontitis, is known to facilitate lipid accumulation, augment immune responses, and induce insulin resistance, thereby exacerbating fibrosis in cases of periodontitis-associated NAFLD. The influence of oral microbiota on NAFLD via the “oral-gut-liver” axis is gaining recognition, offering a novel perspective for NAFLD management through microbial imbalance correction. This review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms, emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.

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Effect of the Progression of Fusobacterium nucleatum–induced Apical Periodontitis on the Gut Microbiota

Cited by 12 publications

References 32 publications

The interplay between oral microbiota, gut microbiota and systematic diseases

The interplay between oral microbiota, gut microbiota and systematic diseases

The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review

Multifunctional role of oral bacteria in the progression of non-alcoholic fatty liver disease

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