Effect of the size and interface composition of milk fat globules on their in vitro digestion by the human pancreatic lipase: Native versus homogenized milk fat globules

Milk Polar Lipids Affect In Vitro Digestive Lipolysis and Postprandial Lipid Metabolism in Mice

“…The MPL emulsion presented a 10-fold higher dAUC of intestinal TG hydrolysis compared with the SPL emulsion. This result appears in agreement with previous work showing an enhancing effect of the preliminary hydrolysis of native milk fat globules (genuine MPL interface of the milk fat globule membrane) on pancreatic lipase adsorption and activity (45)(46)(47).…”

Rheological behaviour of selected commercially available baby formulas in simulated human digestive system

“…13 larger particle size distribution is assumed to be a result of fat and proteins undergoing disruption, flocculation, dissociation and coalescence during digestion as reported elsewhere (Berton et al, 2012;Ye, Cui, & Singh, 2010). …”

Fatty Acid Composition, Fat Globule Size and Reactive Oxygen Species-Scavenging Activity of Mare Milk: A Longitudinal Study

“…HM fat globules have an average diameter of 4µm [1] while for CM it is of 3-5 µm. Dimension of fat globules are very important for lipid digestion by human pancreatic lipase (hPL) as discovered by Berton et al [13]. In particular, the catalytic efficiency of hPL is 4.6-fold higher on small (1.8 µm) than large (6.7 µm) native milk fat globules, so MM should be more easily to digest than CM because of smaller fat globules dimension.…”

“…Despite a plethora of results for CM and HM fat constituents, the composition of MM fat have been occasionally analyzed, mainly when different periods of lactation are considered [10,11]. The literature regarding MM fat characteristics basically lacks a deep analysis of milk fat globule dimensional parameters: the importance in determining such values is not only linked to a commercial aspect, as reported for bovine dairy products [12], but also to physiological cues, since the catalytic capacity of pancreatic lipase is strictly connected to the fat globule dimension and the presence of a phospholipid membrane [13].…”