Effect of the specific infant formula mixture of oligosaccharides on local immunity and development of allergic and infectious disease in young children: randomized study

Ivakhnenko, O.S.; Nyankovskyy, S.L.

doi:10.1016/j.pepo.2013.07.002

Cited by 46 publications

(43 citation statements)

References 13 publications

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“…Galacto-and long chain fructo-oligosaccharides in infant formula administered in a double-blind, randomized, placebo-controlled trial of 259 infants, showed reduced incidence of atopic dermatitis, wheezing and urticaria to less than 50% of the incidence in nonprebiotic formula fed infants. 100,101 In a prospective, double blind, placebo-controlled fashion, not as yet replicated, healthy term infants at risk of atopy fed prebioticsupplemented hypoallergenic formula for 6 months had a greater than five-fold reduction in prevalence of allergies five years after feeding. 102 [H3] Increased mineral absorption.…”

Section: [H1] Prebioticsmentioning

confidence: 99%

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Sanders¹,

Merenstein

Reid

et al. 2019

Nat Rev Gastroenterol Hepatol

1,273

740

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Probiotics and prebiotics are microbiota management tools for improved host health. They target gastrointestinal effects via the gut, although direct application to other sites such as the oral cavity, vaginal tract and skin are being explored. Here, we describe gut-derived effects in humans. In the past decade, research on the gut microbiome has rapidly accumulated, accompanied by increased interest in probiotics and prebiotics as a means to modulate the gut microbiota. Given the importance of these approaches for public health, it is timely to reiterate factual and supporting information on their clinical application and use. In this Review, we discuss scientific evidence on probiotics and prebiotics, including mechanistic insights into health effects. Strains of Lactobacillus, Bifidobacterium, and Saccharomyces have a long history of safe and effective use as probiotics, but Roseburia spp., Akkermansia spp., Propionibacterium spp. and Faecalibacterium spp. show promise. For prebiotics, glucans and fructans are well proven with evidence building on prebiotic effects of other substances (e.g. oligomers of mannose, glucose, xylose, pectin, starches, human milk; and polyphenols). 2 Key Points  The human gut microbiota is integral to health and is associated with a variety of diseases  Therapeutic and prophylactic effects of some probiotics and prebiotics for a variety of gut-related disorders might be, at least in part, mediated through modification of the microbiota and/or its function  Probiotic microorganisms act via a variety of means, including modulation of immune function, production of organic acids and antimicrobial compounds, interaction with resident microbiota, interfacing with the host, improving gut barrier integrity and enzyme formation  Prebiotics are substrates that are selectively utilized by host microorganisms conferring a health benefit; prebiotic effects include defence against pathogens, immune modulation, mineral absorption, bowel function, metabolic effects and satiety  Use of some probiotics and prebiotics is justified by robust assessments of efficacy, but not all products have been validated; the goal is evidence-based use by healthcare professionals

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Section: [H1] Prebioticsmentioning

confidence: 99%

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Sanders¹,

Merenstein

Reid

et al. 2019

Nat Rev Gastroenterol Hepatol

1,273

740

View full text Add to dashboard Cite

show abstract

“…Two studies reported development of wheezing/asthma . Prebiotics were found to reduce the risk of asthma or wheezing when compared to the control group (RR, 0.37; 95% CI, 0.17 to 0.80; 249 participants; 2 trials), but precision was a concern due to a low number of events.…”

Section: Resultsmentioning

confidence: 99%

“…Only one study reported the development of food allergy defining it as “gastrointestinal symptoms of food allergy” as reported by parents. In this trial, prebiotics reduced the risk of food allergy symptoms when compared to placebo (RR, 0.28; 95% CI 0.08 to 1; 115 participants; 1 trial), but it is also uncertain to what extent this outcome reflected a true food allergy.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies reported development of wheezing/asthma. 20,22 Prebiotics were found to reduce the risk of asthma or wheezing when compared to the control group (RR, 0.37; 95% CI, 0.17 to 0.80; 249 participants; 2 trials), but precision was a concern due to a low number of events. Both studies used "recurrent wheezing" as their end-point of interest defining this outcome as "3 or more physician-diagnosed episodes in 2 years," and their data were obtained from both patients' self-reports and/or clinical records.…”

Section: Use Of Prebiotics In Infantsmentioning

confidence: 99%

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Prebiotics for the prevention of allergies: A systematic review and meta‐analysis of randomized controlled trials

Cuello‐García

Fiocchi

Pawankar

et al. 2017

Clin Experimental Allergy

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“…Ivakhnenko et al . also found reduced cumulative incidence of eczema at 18 months of age in an open RCT of non‐breastfed children fed standard formula with scGOS/lcFOS compared with standard formula without any addition. In a double‐blind RCT including children at low risk of atopy (based on the absence of allergic heredity), there was a transient benefit of prebiotics (non‐hydrolysed cow's milk‐based formula with scGOS and lcFOS and long‐chain fructo‐OS, ratio 9 : 1, plus specific pectin‐derived acidic oligosaccharides) on eczema in the first year of life , but this was not sustained at preschool age .…”

Section: Primary Prevention Studies Using Prebioticsmentioning

confidence: 79%

Pre‐ and probiotics for allergy prevention: time to revisit recommendations?

Forsberg

West

Prescott

et al. 2016

Clin Experimental Allergy

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Reduced intensity and diversity of microbial exposure is considered a major factor driving abnormal postnatal immune maturation and increasing allergy prevalence, particularly in more affluent regions. Quantitatively the largest important source of early immune-microbial interaction, the gut microbiota is of particular interest in this context, with variations in composition and diversity in the first months of life associated with subsequent allergy development. Attempting to restore the health consequences of the 'dysbiotic drift' in modern society, interventions modulating gut microbiota for allergy prevention have been evaluated in several randomized placebo controlled trials. In this review, we provide an Accepted ArticleThis article is protected by copyright. All rights reserved.overview of these trials and discuss recommendations from international expert bodies regarding prebiotic, probiotic and synbiotic interventions. Recent guidelines from the World Allergy Organization recommend the use of probiotics for the primary prevention of eczema in pregnant and breastfeeding mothers of infants at high risk for developing allergy and in high risk infants. It is however stressed that these recommendations are conditional, based on very low quality evidence and great heterogeneity between studies, which also impedes specific and practical advice to consumers on the most effective regimens. We discuss how the choice of probiotic strains, timing and duration of administration can critically influence the outcome due to different effects on immune modulation and gut microbiota composition.Furthermore, we propose strategies to potentially improve allergy preventive effects and enable future evidence-based implementation.

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Effect of the specific infant formula mixture of oligosaccharides on local immunity and development of allergic and infectious disease in young children: randomized study

Cited by 46 publications

References 13 publications

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Prebiotics for the prevention of allergies: A systematic review and meta‐analysis of randomized controlled trials

Pre‐ and probiotics for allergy prevention: time to revisit recommendations?

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