Effect of the sterol demethylation-inhibiting fungicide fenarimol on selected biochemical parameters in rats

Arı, Ferda; Dere, Egemen

doi:10.2298/avb1001031a

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Again, as a result of studies in experimental animals, fenarimol has been shown to have teratogenic and oncogenic effects on reproduction and inhibit aromatase activity in male rats [20]. In addition, as a result of a previous study conducted by our group, it was shown that hepatic marker enzyme activities (ALP, ALT, AST and CK) and some biochemical parameters in serum were affected in fenarimol-induced rats [21].…”

Section: Introductionmentioning

confidence: 87%

Glutathione S-Transferase Activity in Tissues of Rats Exposed to Fenarimol

Ozcelebi

Arı

Dere

2021

Braz. arch. biol. technol.

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The unconscious use of pesticides causes various adverse effects on non-target organisms, including humans. Enzymes that control metabolism become the target of the pesticide and the organs are damaged due to toxic effects. Glutathione s-transferase (GST, EC 2.5.1.18), an important enzyme of the detoxification mechanism and antioxidant defense system, can be affected by such toxic substances. Therefore, the effect of fenarimol on GST enzyme activity was investigated in our study. For this, 200 mg/kg fenarimol was administered intraperitoneally to male and female rats at different periods (2, 4, 8, 16, 32, 64 and 72 hours). After application, GST enzyme activity was analysed in the liver, kidney, brain and small intestine tissues of the rats. According to our results, activation (liver, kidney, small intestine) or inhibition (brain) of the generally GST enzyme was observed in the tissues of rats exposed to fenarimol. It is thought that the increase and/or decrease in this enzyme activity may be the cause of the toxic effect of fenarimol.

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Section: Introductionmentioning

confidence: 87%

Glutathione S-Transferase Activity in Tissues of Rats Exposed to Fenarimol

Ozcelebi

Arı

Dere

2021

Braz. arch. biol. technol.

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Enantioselective separation and simultaneous determination of fenarimol and nuarimol in fruits, vegetables, and soil by liquid chromatography–tandem mass spectrometry

et al. 2012

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A method for simultaneous enantioselective determination of fenarimol and nuarimol in apple, grape, cucumber, tomato, and soil was developed using liquid chromatography-tandem mass spectrometry. The enantioseparation results of the two fungicides through three different cellulose-based chiral columns are discussed. The influence of column temperature on the resolution of the enantiomers of the two fungicides was examined. Complete enantioseparation of the two fungicides' enantiomers was obtained on a cellulose tris(4-methylbenzoate) column (Lux Cellulose-3) at 25 °C using methanol and 0.1 % formic acid solution (80:20, v/v) as mobile phase. The linearity, matrix effect, recovery, and precision were evaluated. Good linearity was obtained over the concentration range of 1-500 μg L(-1) for each enantiomer in the standard solution and sample matrix calibration solution. There was no significant matrix effect in apple, grape, cucumber, or tomato samples, but signal suppression was typically observed with the soil extracts. The mean recoveries, repeatability, and reproducibility were 76.5-103 %, 2.1-9.0 %, and 4.2-11.8 %, respectively. The limit of quantification for enantiomers of the two fungicides in fruits, vegetables and soil was 5 μg kg(-1). Moreover, the absolute configuration of the enantiomers of fenarimol and nuarimol was determined from a combination of experimentally determined and predicted electronic circular dichroism spectra.

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Effect of the sterol demethylation-inhibiting fungicide fenarimol on selected biochemical parameters in rats

Cited by 2 publications

References 25 publications

Glutathione S-Transferase Activity in Tissues of Rats Exposed to Fenarimol

Glutathione S-Transferase Activity in Tissues of Rats Exposed to Fenarimol

Enantioselective separation and simultaneous determination of fenarimol and nuarimol in fruits, vegetables, and soil by liquid chromatography–tandem mass spectrometry

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